Volume 42 Supplement 1

Proceedings of the 13th Internordic Symposium of the Nordic Committee for Veterinary Scientific Cooperation (NKVet)

Open Access

Relationships Between Animal Health Monitoring and the Risk Assessment Process

  • K. D. C. Stärk1 and
  • M. D. Salman2
Acta Veterinaria Scandinavica200142(Suppl 1):S71

DOI: 10.1186/1751-0147-42-S1-S71

Published: 31 March 2001

Abstract

Risk assessment is part of the risk analysis process as it is used in veterinary medicine to estimate risks related to international trade and food safety. Data from monitoring and surveillance systems (MO&SS) are used throughout the risk assessment process for hazard identification, release assessment, exposure assessment and consequence assessment. As the quality of risk assessments depends to a large extent on the availability and quality of input data, there is a close relationship between MO&SS and risk assessment. In order to improve the quality of risk assessments, MO&SS should be designed according to minimum quality standards. Second, recent scientific developments on state-of-the-art design and analysis of surveys need to be translated into field applications and legislation. Finally, knowledge about the risk assessment process among MO&SS planners and managers should be promoted in order to assure high-quality data.

Keywords

Risk assessment data quality disease monitoring disease surveillance survey design animal health

Introduction

Risk assessment is part of the risk analysis process, which also includes risk management and risk communication. Risk assessment in veterinary medicine is mainly used to estimate risks related to international trade and food safety. Risk in the risk analysis context is defined as the probability of an adverse event and the magnitude of the consequences [21, 6]. The objective of risk assessment is to estimate both these elements in order to provide input to an underlying decision problem, for example: whether or not to permit the import of a certain commodity. A risk assessment is expected to take into account all available information, to systematically structure and analyse it and to provide a scientifically sound, objective outcome. All steps of a risk assessment need to be documented in a transparent fashion such that the results are understandable and reproducible [31].

One of the limitations of risk assessment, however, is the lack of reliable and high-quality data that can be used as input [11, 28]. Furthermore, biases introduced by sub-optimal data collection procedures or inadequate data processing and analysis can reduce the accuracy of risk estimates [11].

Input data for risk assessments can be obtained from disease monitoring systems. Disease monitoring is defined as routine recording, analysis and distribution of data related to health or disease of a defined population in a defined area at a specific point in time [13]. Disease surveillance is a special case of monitoring where pre-defined action will be taken as soon as a specified threshold is passed. Therefore, surveillance is always part of a disease control programme. For exotic diseases, the threshold value to initiate action is typically zero, i.e. there will be eradication measures taken as soon as the first case is diagnosed.

The objective of this article is to elaborate the relationship between monitoring and surveillance systems (MO&SS) and risk assessment. The requirements to be fulfilled by MO&SS in order to support high-quality risk assessments are discussed.

Monitoring and surveillance data and their effect on the risk assessment process

The type of input data required to conduct risk assessments depends on the underlying decision problem, but in principle, it can be grouped into data for the following steps of the risk assessment process: hazard identification, release assessment, exposure assessment and consequence assessment [11]. Data generated by MO&SS can be used in all these risk assessment steps (Error! Unknown switch argument.). The second major source of information for risk assessments are targeted epidemiological, toxicological or microbiological studies [26], the adequate design of which is important and thus an area with potential for improvement in order to reduce imprecision in risk assessments [23, 32].

Hazard identification is the first step in the risk assessment process (Table 1). This step requires a thorough evaluation of existing data and information about the potential hazard to answer the question: "What can go wrong?". Only hazards that are identified will be included in the risk assessment. Hazard identification is therefore a very influential step. Monitoring systems can form the basis for data gathering for the hazard identification. For example, monitoring of antibiotic resistance in animals is used in the assessment of the risk of antibiotic resistance in human medicine. Such a monitoring system is, for example, currently run in Denmark [1]. One hazard under consideration in this country is the use of antibiotics in veterinary medicine, mainly their use as growth promoters. Not all antibiotics that are currently used are identified as hazards at this stage, but depending on the monitoring results in human and animal populations, products other than the ones currently listed by the European Union (EU) (Directive 70/542/EEC with recent amendments) could be phased out. Consequently, MO&SS can play a major role to determine the final recommendation resulting from a risk assessment process.
Table 1

Input data for risk assessments provided through animal disease monitoring and surveillance systems

 

Input provided through monitoring and surveillance systems

Risk assessment step

Animal trade risk assessment

Food safety risk assessment

Hazard identification

Occurrence of risk indicators

Occurrence of risk indicators

 

Level and quality of detection of the agent/disease in an animal population

Level and quality of detection of the agent in an animal or product

Release assessment

Prevalence/incidence of agent or disease in exporting country

Prevalence of agent or substance at all points of the production system

 

Strain differences if applicable

Detection level of the agent at each point of production

 

Level and quality of detection of the disease on a population basis

 

Exposure assessment

Prevalence/incidence of agent or disease in importing country (endemic level of the agent in the host population)

Prevalence of agent or substance in products

 

Prevalence of agent in the environment (water, air, wildlife)

Prevalence of agent or substance in the environment (water, air)

 

Strain differences if applicable

Human behaviour and consumption patterns

Consequence assessment

Associated risk factors for the spread of the disease

Incidence of human cases

 

Economic parameters that are affected by the exposure to or introduction of the disease

Severity of human cases

  

Cost of human cases

The hazard analysis critical control point (HACCP) approach is today used throughout the food processing industry [19]. HACCP systems focus on factors (hazards) that have been shown to contribute to foodborne illness. In a second step critical control points are identified. Critical control points are production steps where interventions can be applied. HACCP also includes data recording to monitor the production safety. HACCP systems can therefore be considered to be MO&SS [17]. These data can be used in risk assessments and, reciprocally, risk assessment techniques can also be used to develop HACCP programmes [22].

Most frequently, MO&SS data are used to document the occurrence of agents or substances in the release and exposure assessment part of a risk assessment. With regard to international trade questions, such data are routinely extracted from sources such as the animal health yearbook published by the Office International des Epizooties (OIE, for example, [2]). However, this publication is limited with respect to timeliness and accuracy, as it heavily depends on the quality of veterinary services and the MO&SS in place in individual countries. [27] demonstrated the influence of the quality of surveillance on the time needed for the detection of the first case of a newly introduced disease. Using outbreaks of Salmonella dublin as an example (an exotic agent in the country under consideration), it was shown, that a reduced surveillance programme could increase the median time to diagnosis from 4 weeks to 40 weeks. This demonstrates that background information on the design and conduct of MO&SS is necessary in order to be able to establish the level of confidence one can have into MO&SS results. This type of information, however, is not included in the animal health yearbook. It is therefore preferable to obtain data directly from the countries under consideration for import/export.

Regarding endemic diseases, monitoring of strain differences can also be a useful tool for the release assessment step of the risk assessment process. This is particularly important if differences between countries exist. For example, in Denmark the current monitoring system with respect to Salmonella enterica in swine includes strain differentiation. All salmonella isolates are phage-typed and a stamping-out strategy was adopted for multiresistant Salmonella enterica Typhimurium DT104 [24]. Imported commodities that contain multiresistant Salmonella enterica Typhimurium DT104 are no longer acceptable. This decision is based on the zero prevalence of multiresistant Salmonella enterica Typhimurium DT104 in food in Denmark and the health risk posed by this strain to affected humans. If strain differences in Denmark were not monitored, there would be no basis for applying such specific risk management strategies.

With respect to toxic substances and residues in food, MO&SS are being maintained in many countries. MO&SS for zoonotic agents, on the other hand, have gained attention only in recent years and mainly in Scandinavian countries. Additionally, the systems that are in place for residue and zoonotic agent monitoring are almost exclusively based on end product control. Monitoring of the entire production chain, however, is necessary for risk management measures such as the development of HACCP systems [18]. Such systems require the herd of origin to be integrated in the monitoring process [8]. Integrated programs of this kind are only very rarely implemented. One example is the Salmonella enterica reduction programme in Denmark [25].

Ensuring high-quality input for risk assessments

Quality of data is dependent on the methods and procedures used for data collection [32]. All MO&SS should therefore include quality assurance steps. The validity determinants of a MO&SS are similar to those of any epidemiological study, namely proper study design, adequate sample size, representative samples, unbiased measure of outcome, control for confounding factors and correct statistical analysis [23]. Additionally, there are some analytical issues that are specific for animal populations. For example, animal populations are typically aggregated and mobile and consequently, disease can occur in clusters in time and space [28]. A series of articles addressing these analytical issues have recently been published (for example, [15, 14, 9, 10, 7]), but the transfer of scientific knowledge to routine data collection has yet to occur. The new principles for sampling (e.g. cluster sampling) and analysis need to be integrated in national MO&SS legislation as well as in international MO&SS guidelines, for example, in the International Animal Health Code [3].

Clearly, there are many different types of MO&SS and there is no easy way to assess their quality. Nevertheless there is a need to evaluate MO&SS according to specific criteria in order to be able to interpret data correctly [30, 4]. [20] suggested that the ideal national MO&SS should include aspects for the surveillance of disease agents, for host monitoring (e.g. livestock population census) and environmental assessments. Based on this principle, he suggested a catalogue of criteria to assess the level of implementation of MO&SS and the quality of veterinary services in a country. The issue of MO&SS evaluation was recently further contemplated by [16]. This author suggested the use of critical control points similar to an HACCP assessment to evaluate the quality of a MO&SS. Suggested critical control points were, for example, sampling, co-ordination and awareness, screening and diagnosis, as well as data collection, recording and analysis. This method was successfully applied to three existing surveillance systems. Based on the evaluation, recommendations were given in order to improve the quality of the programmes.

These two examples document the need for a quality assessment of MO&SS. If MO&SS were designed according to accepted standards, the data produced by these programmes would be of comparable quality and could be more readily used in risk assessments. In an additional step, MO&SS applying accepted standards could even be 'certified' by an independent organisation such as the OIE.

In order to provide better and higher quality input for risk assessments, MO&SS also need to be designed with the application of the data in mind. Therefore, people involved in data collection and analysis should not only know about survey design, but also have a basic understanding of risk assessment and the respective data needs [32].

Discussion and conclusions

Risk assessment as a scientific framework is being promoted in the international trade and the food safety arena by the World Trade Organisation [12], the OIE, the Codex Alimentarius Commission and the EU. These organisations are recognising the need for good quality data input and are promoting MO&SS as data sources. For example, the EU has listed the need for monitoring systems in a recent resolution for an antibiotic resistance strategy [5]. Similarly, the OIE writes in the latest edition of the International Animal Health Code (1999b) that each country that plans to export animals or animal products needs to supply information on its MO&SSHYPERLINK. This is necessary for the importing country to review the evidence for freedom from disease and to assess the related risk [30]. The OIE has also developed standards for the surveillance of rinderpest and contagious bovine pleuropneumonia http://www.oie.int/Norms/a_surv.htm, and standards regarding other diseases are likely to follow.

As MO&SS are to be used as data sources for risk assessments the quality of the data provided needs to be known. The validity of data consists of both internal and external validity. An assessment of data validity is suggested to be part of every MO&SS. This issue becomes even more pressing if data are to be used in risk assessments that need to be justifiable in the international trade arena. If minimal standards for MO&SS were specified, risk assessments could be readily compared between countries. This would support harmonisation of trade, one of the key objectives of the Sanitary and Phytosanitary Agreement governed by the World Trade Organisation. In the long term, even a certification of MO&SS could be envisaged.

The analysis of data generated by MO&SS or a survey is not always straightforward and specific issues have to be addressed. Although progress is being made in this area, the work remains largely limited to academic exercises and is not yet widely applied. In order to improve the knowledge transfer from research to application, scientific results have to be translated into practical examples, and user-friendly software tools need to be developed for field use.

Finally, everybody involved with the development of MO&SS, with data collection and analysis should have a basic understanding of the risk assessment process in order to appreciate the significance of data quality. Also feedback of risk assessment results to MO&SS staff needs to be strengthened. It has been shown in many examples that this increases motivation among data collectors and thus indirectly improves data quality.

The use of MO&SS data for risk assessment will ultimately support risk management, i.e. the selection and implementation of risk reduction measures. After risk reduction measures are implemented, MO&SS can again be used to measure the efficacy of these interventions. This is very much according to the original aim of surveillance, namely to provide information for action [29].

Authors’ Affiliations

(1)
Danish Bacon and Meat Council
(2)
Department of Environmental Health, College of Veterinary Medicine and Biomedical Sciences, Colorado State University

References

  1. Anonymous: DANMAP 97 – Consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, food and humans in Denmark. 1998, Danish Zoonosis Centre, Copenhagen, DenmarkGoogle Scholar
  2. Anonymous: World animal health. 1999, Office International des Epizooties, ParisGoogle Scholar
  3. Anonymous: International Animal Health Code. 1999, Office International des Epizooties, Paris, [http://www.oie.int]8Google Scholar
  4. Anonymous: Summary of the 1998 animal health monitoring and surveillance work conference. 1999, USDA:APHIS:VSGoogle Scholar
  5. Anonymous: Council resolution of 8 June 1999 on antibiotic resistance 'A strategy against the microbial threat' (1999/C 195/01). Offic J Europ Comm. 1999, C195: 1-3. 13.7.1999dGoogle Scholar
  6. Ahl AS, Scree PS, Gipson PS, McDowell RM, Miller L, McElvaine MD: Standardization of nomenclature for animal health risk analysis. Rev Sci Tech Off Int Epiz. 1993, 12: 1045-1053.Google Scholar
  7. Audigé L, Beckett S: A quantitative assessment of the validity of animal-health surveys using stochastic modelling. Prev Vet Med. 1999, 38: 259-276. 10.1016/S0167-5877(98)00135-4.View ArticlePubMedGoogle Scholar
  8. Blaha T: Epidemiology and quality assurance application to food safety. Prev Vet Med. 1999, 39: 81-92. 10.1016/S0167-5877(98)00150-0.View ArticlePubMedGoogle Scholar
  9. Cameron AR, Baldock FC: A new probability formula for surveys to substantiate freedom from disease. Prev Vet Med. 1998, 34: 1-17. 10.1016/S0167-5877(97)00081-0.View ArticlePubMedGoogle Scholar
  10. Cameron AR, Baldock FC: Two-stage sampling in surveys to substantiate freedom from disease. Prev Vet Med. 1998, 34: 19-30. 10.1016/S0167-5877(97)00073-1.View ArticlePubMedGoogle Scholar
  11. Covello VT, Merkhofer MW: Risk Assessment Methods – Approaches for Assessing Health and Environmental Risks. 1993, Plenum Press, New YorkGoogle Scholar
  12. Campos H: The ten commandments of the Sanitary and Phytosanitary Agreement of the World Trade Organization. Working paper, 2nd FAO E-Conference on Veterinary Services. 1998, [http://www.fao.org/ag/aga/agah/Vets-l-2/Contents/Default.htm]Google Scholar
  13. Christensen J: Epidemiological concepts regarding disease monitoring and surveillance. Acta vet Scand.Google Scholar
  14. Dargatz DS, Hill GW: Analysis of survey data. Prev Vet Med. 1996, 28: 225-237. 10.1016/0167-5877(96)01052-5.View ArticleGoogle Scholar
  15. Donald AW, Gardner IA, Wiggins AD: Cut-off points for aggregate herd testing in the presence of disease clustering and correlation of test errors. Prev Vet Med. 1994, 19: 167-87. 10.1016/0167-5877(94)90087-6.View ArticleGoogle Scholar
  16. Dufour B: Technical and economic evaluation method for use in improving infectious animal disease surveillance networks. Vet Res. 1999, 30: 27-37.PubMedGoogle Scholar
  17. Guzewich JJ, Bryan FL, Todd ECD: Surveillance of foodborne disease: I. purposes and types of surveillance systems and networks. J Food Prot. 1997, 60: 555-566.Google Scholar
  18. Hathaway SC: Risk analysis and meat hygiene. Rev Sci Tech Off Int Epiz. 1993, 12: 1265-1290.Google Scholar
  19. Hogue AT, White PL, Heminover JA: Pathogen reduction and hazard analysis and critical control point (HACCP) systems for meat and poultry. Vet Clin North Am Food Anim Pract. 1998, 14: 151-164.View ArticlePubMedGoogle Scholar
  20. Hueston WD: Assessment of national systems for the surveillance and monitoring of animal health. Rev sci tech Off int Epiz. 1993, 12: 1187-96.Google Scholar
  21. Kaplan S, Garrick BJ: On the quantitative definition of risk. Risk Anal. 1981, 1: 11-27. 10.1111/j.1539-6924.1981.tb01350.x.View ArticleGoogle Scholar
  22. Mayes T: Risk analysis in HACCP: burden or benefit?. Food Control. 1998, 9: 171-175. 10.1016/S0956-7135(97)00055-8.View ArticleGoogle Scholar
  23. Mundt KA, Tritschler JP, Dell LD: Validity of epidemiological data in risk assessment applications. Hum Ecol Risk Assess. 1998, 4: 675-683. 10.1080/10807039891284550.View ArticleGoogle Scholar
  24. Møgelmose V, Nielsen B, Sørensen LL, Dahl J, Wingstrand A, Johansen M, Pihl K, Nielsen V, Svensmark B, Udesen F, Larsen LP, Baggesen DL: Eradication of multiresistant Salmonlla Typhimurium DT104 infections in 15 Danish swine herds. Proc 3rd Int Symp Epid Contr Salm Pork, Washington. 1999, 367-369.Google Scholar
  25. Nielsen B, Wegener HC: Public health and pork and pork products: regional perspectives of Denmark. Rev sci tech Off int Epiz. 1997, 16: 513-24.Google Scholar
  26. Roseman JM: What can be done to ensure the usefulness of epidemiologic data for risk assessment purposes?. Hum Ecol Risk Assess. 1998, 4: 737-746. 10.1080/10807039891284596.View ArticleGoogle Scholar
  27. Sanson RL, Thornton RN: A modelling approach to the quantification of the benefits of a national surveillance programme. Prev Vet Med. 1997, 30: 37-47. 10.1016/S0167-5877(96)01083-5.View ArticlePubMedGoogle Scholar
  28. Salman M, Ruppaner R: Risk management and decision analysis in animal health. Proc Ann Conf Soc Vet Epid Prev Med, Bristol. 1999, 1-6.Google Scholar
  29. Thacker SB, Gregg MB: Implementing the concepts of William Farr: the contributions of Alexander D. Langmuir to public health surveillance and communications. Americ J Epidemiol. 1996, 144 (Suppl): 23-8.View ArticleGoogle Scholar
  30. Welte VR, Otte J, Ward D: Supporting claims of freedom from disease. Working paper, 2nd FAO E-Conference on Veterinary Services. 1998, [http://www.fao.org/ag/aga/agah/Vets-l-2/Contents/Default.htm]Google Scholar
  31. Wooldridge M: Risk analysis, risk assessment, animal health and the decision-making process. State Vet J. 1996, 12: 4-6.Google Scholar
  32. Younes M, Sonich-Mullin C: Reducing imprecision in risk assessment – A plea for focused science. Hum Ecol Risk Assess. 1998, 4: 259-262. 10.1080/10807039891284334.View ArticleGoogle Scholar

Copyright

© The Author(s) 2001