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Active Mammary Excretion of N4-Acetylated p-Aminohippuric Acid*)
Acta Veterinaria Scandinavica volume 10, pages 193–194 (1969)
Abstract
Different excretion patterns were observed for p-amino- hippuric acid and its acetylated metabolite in mammary excretion experiments in goats and cows. The excretion of p-aminohippuric acid conformed to passive diffusion of the non-protein bound and un-ionized fraction (Rasmussen 1958, 1966) as described by Miller et al. (1967). Thus, the p-aminohippuric acid (pKa 3.8) appeared in ultrafiltrates of milk in concentrations 1/4—1/10 of the concentrations in ultrafiltrates of blood plasma. The concentrations of acetylated p-aminohippuric acid (pKa 3.9) in ultrafiltrates of milk were on the other hand equal to or higher than in ultrafiltrates of blood plasma.
References
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Miller, G.E., N.C. Banerjee & C.M. Stowe: Diffusion of certain weak organic acids and bases across the bovine mammary gland membrane after systemic administration. J. Pharmacol, exp. Ther. 1967, 157, 245–253.
Rasmussen, Folke: Mammary excretion of sulphonamides. Acta Pharmacol. (Kbh.) 1958, 15, 139–148.
Rasmussen, Folke: Studies on the mammary excretion and absorption of drugs. Thesis. Copenhagen 1966.
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Rasmussen, F. Active Mammary Excretion of N4-Acetylated p-Aminohippuric Acid*). Acta Vet Scand 10, 193–194 (1969). https://doi.org/10.1186/BF03548289
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DOI: https://doi.org/10.1186/BF03548289