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Table 4 Overview of all combinations used

From: Determination of a safe sedative combination of dexmedetomidine, ketamine and butorphanol for minor procedures in dogs by use of a stepwise optimization method

Comb.

n

Sex,

No. F/M

Mean age, yr (± SD)*

mean weight, kg (± SD)§

Type of procedure

No. CT/Rx/Surg

mean duration of

Sedation, min (± SD)#

1st propofol before

No. 0/20/40/>40 min

Median HR

Median RR

Median SpO2

Median MAP

A

6

3/3

4 (± 2.66)

27.02 (± 20.01)

1/4/1

51.50 (± 14.28)

1/2/0/3

67.9

16.5

111.1

96.6

B

6

2/4

3.3 (± 2.77)

36.40 (± 29.57)

0/5/1

89.50 (± 46.09)

0/2/3/1

57

12.4

88.2

97.7

C

8

5/3

5.03 (± 3.12)

26.25 (± 14.68)

3/5/0

65.25 (± 15.22)

0/3/2/3

59.4

15.3

99.5

97.3

D

6

3/3

5.74 (± 2.47)

31.15 (16.93)

1/5/0

94.33 (± 16.83)

1/0/3/2

50.3

13.4

89.6

97.4

E

6

4/2

4.21 (± 2.66)

14.75 (± 8.41)

0/3/3

65.00 (± 34.19)

0/1/2/3

57.9

14.4

99.1

97.4

F

6

5/1

3.72 (± 2.66)

(31.83 (± 16.37)

1/5/0

82.17 (± 26.93)

1/1/2/2

58.6

15.7

93.6

97.7

G

6

1/5

6.40 (± 3.8)

40.81 (± 16.53)

2/3/1

72.17 (± 26.42)

0/0/1/5

53.3

11.0

112.1

96.6

H

6

5/1

2.38 (± 1.66)

26.62 (± 12.57)

1/2/3

51.83 (± 10.63)

0/0/1/5

58.6

12.9

108.6

96.8

J

6

3/3

3.66 (± 3.32)

22.95 (± 12.01)

0/4/2

69.50 (± 21.31)

1/1/3/1

37.6

13.4

88.7

97.6

K

6

4/2

4.42 (± 3.34)

30.00 (± 6.20)

0/5/1

77.83 (± 23.64)

0/1/1/4

49.4

12.0

95.9

97.2

L

6

4/2

4.41 (± 3.47)

35.22 (± 15.02)

1/4/1

80.17 (± 30.73)

0/0/3/3

46.4

11.8

87.8

97.6

M

6

3/3

5.50 (± 3.48)

27.95 (± 10.64)

2/4/0

80.83 (± 28.58)

2/1/1/2

45.5

14.5

101.0

96.9

L2

6

4/2

3.98 (± 1.56)

36.07 (± 10.34)

0/5/1

75.00 (± 23.77)

0/0/2/4

47.2

13.1

95.3

97.2

L3

100

47/53

4.37 (± 3.13)

32.21 (± 15.54)

75/3/25

71.98 (± 22.75)

0/1/27/29

57.8

15.5

96.7

86.9

  1. *no significant difference between groups in terms of age (P = 0.617)
  2. §no significant difference between groups in terms of weight (P = 0.35)
  3. #no significant difference between groups in terms of duration of sedation (P = 0.05)
  4. The empirically chosen combinations A-H were analyzed in the first complex. Combinations J-M were calculated during the stepwise optimization procedure. Ranges (minimum-maximum) are reported for age, weight, and duration of anaesthesia. The numbers of animals per category are shown for sex, type of procedure, and first propofol use. Types of procedures are categorized into computertomographic examinations (CT), radiographs (Rx), and small surgical procedures (Surg) such as skin biopsies, wound treatments or external fixation removals