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Table 1a Virological and serological findings in vaccinated calves during acute outbreak of respiratory disease in herd A (a) and herd B (b). Nasal swabs were taken at the acute phase (20/26 Jan) and paired serum samples were taken at the acute phase and one month later (18/19 Feb). The nasal swabs were analysed for the presence of bovine respiratory syncytial virus (BRSV), bovine corona virus (BCV) and parainfluenza-3 virus (PI-3) antigen (Ag) by ELISA. Serum samples were analysed for the presence of antibodies against BRSV (IgM, IgA, IgG1, IgG2 isotypes) and neutralising antibodies (SNT), BCV (Ab) and PI-3 (Ab). Significant change in antibody titers were defined as either sero-conversion (from 0 to any titer) or at least four-fold rises. Dead: The calf died between the two sampling dates. NA: Not applicable. * Insufficient amount of sample for testing.

From: Bovine Respiratory Syncytial Virus (BRSV) Pneumonia in Beef Calf Herds Despite Vaccination

  BRSV Ag BRSV-IgM BRSV-IgA BRSV-IgG1 BRSV-IgG2 BRSV-SNT
Calf # 20 Jan 20 Jan 19 Feb 20 Jan 19 Feb 20 Jan 19 Feb Rise 20 Jan 19 Feb Rise 20 Jan 19 Feb Rise
332 + 0 Dead 0 Dead 0 Dead NA 0 Dead NA 64 Dead NA
338R 0 0 0 0 40 80 2560 YES 0 2560 YES 16 2048 YES
325 + 0 * 0 0 40 160 YES 0 * NA 16 1024 YES
340 0 0 0 0 20 160 1280 YES 40 2560 YES 64 256 YES
244N 0 0 Dead 0 Dead 40 Dead NA 0 Dead NA 8 Dead NA
416 0 0 0 0 20 20 2560 YES 0 640 YES 4 128 YES
421H 0 0 0 0 160 20 160 YES 0 10240 YES 16 2048 YES
426H 0 0 0 0 0 40 160 YES 40 160 YES 256 32 NO
407H 0 0 0 0 0 0 320 YES 0 1280 YES 2 1024 YES
436H 0 0 0 0 0 40 5120 YES 0 40 YES 8 2048 YES
  BCV Ag BCV Ab PI-3 Ag PI-3 Ab       
Calf # 20 jan 20 Jan 19 Feb Rise 20 Jan 20 Jan 19 Feb Rise       
332 0 800 Dead NA 0 0 Dead NA       
338R 0 12800 12800 NO 0 0 0 NO       
325 0 1600 3200 NO 0 8 8 NO       
340 0 3200 1600 NO 0 8 8 NO       
244N 0 3200 Dead NA 0 8 Dead NA       
416 0 1600 1600 NO 0 0 0 NO       
421H 0 3200 3200 NO 0 0 0 NO       
426H 0 800 6400 YES 0 0 0 NO       
407H 0 1600 1600 NO 0 0 0 NO       
436H 0 3200 6400 NO 0 0 0 NO