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Table 1b Virological and serological findings in vaccinated calves during acute outbreak of respiratory disease in herd A (a) and herd B (b). Nasal swabs were taken at the acute phase (20/26 Jan) and paired serum samples were taken at the acute phase and one month later (18/19 Feb). The nasal swabs were analysed for the presence of bovine respiratory syncytial virus (BRSV), bovine corona virus (BCV) and parainfluenza-3 virus (PI-3) antigen (Ag) by ELISA. Serum samples were analysed for the presence of antibodies against BRSV (IgM, IgA, IgG1, IgG2 isotypes) and neutralising antibodies (SNT), BCV (Ab) and PI-3 (Ab). Significant change in antibody titers were defined as either sero-conversion (from 0 to any titer) or at least four-fold rises. Dead: The calf died between the two sampling dates. NA: NOt applicable. * Insufficient amount of sample for testing.

From: Bovine Respiratory Syncytial Virus (BRSV) Pneumonia in Beef Calf Herds Despite Vaccination

  BRSV Ag BRSV-IgM BRSV-IgA BRSV-IgG1 BRSV-IgG2 BRSV-SNT
Calf # 26 Jan 26 Jan 18 Feb 26 Jan 18 Feb 26 Jan 18 Feb Rise 26 Jan 18 Feb Rise 26 Jan 18 Feb Rise
1064/5 0 0 0 * 40 * ≥ 1280 10240 NA * 5120 NA 64 2048 YES
2535/5 0 0 Dead 80 Dead 2560 Dead NA 80 Dead NA 2048 Dead NA
2537/5 0 0 0 0 0 320 320 NO 0 320 YES 128 256 NO
642/5 0 0 Dead 0 Dead 1280 Dead NA 0 Dead NA 64 Dead NA
829/5 0 640 0 80 20 640 160 NO 20 160 YES 64 32 NO
1057 0 0 0 0 0 1280 2560 NO 0 640 YES 256 128 NO
821 0 0 Dead 80 Dead 1280 Dead NA 20 Dead NA 2048 Dead NA
799 0 0 Dead 0 Dead 320 Dead NA 0 Dead NA 64 Dead NA
795 0 320 Dead 80 Dead 5120 Dead NA 0 Dead NA 1024 Dead NA
1317 0 0 0 0 20 640 2560 YES 20 160 YES 8 148 YES
  BCV Ag BCV Ab PI-3 Ag PI-3 Ab       
Calf # 26 jan 26 Jan 18 Feb Rise 26 Jan 26 Jan 18 Feb Rise       
1064/5 0 * ≥ 25600 NA 0 * 0 NA       
2535/5 0 6400 Dead NA 0 0 Dead NA       
2537/5 0 3200 12800 YES 0 0 0 NO       
642/5 0 800 Dead NA 0 0 Dead NA       
829/5 0 800 ≥ 25600 YES 0 0 8 YES       
1057 0 1600 ≥ 25600 YES 0 0 0 NO       
821 0 6400 Dead NA 0 16 Dead NA       
799 0 3200 Dead NA 0 0 Dead NA       
795 0 3200 Dead NA 0 8 Dead NA       
1317 0 12800 12800 NO 0 8 0 NO