Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse

Table 3 Ventilation/perfusion relationship (V_A/Q) data (n = 7)

		Unsedated	Detomidine	Detomidine-butorphanol	GLM – ANOVA
Percentage perfusion of regions with:	Shunt	1.1 ± 0.3	1.3 ± 0.4	1.1 ± 0.4	NS
	Normal V _A /Q	98.8 ± 0.4	98.5 ± 0.6	98.8 ± 0.4	NS
Percentage ventilation of regions with:	Normal V _A /Q	36.0 ± 5.2	30.8 ± 7.5	35.7 ± 7.1	NS
	High V _A /Q	0.3 ± 0.5	2.5 ± 3.8	1.6 ± 2.3	NS
	Dead space	63.6 ± 5.1	66.5 ± 4.2	61.3 ± 4.4 †	p = 0.047
	Log SDQ	0.37 ± 0.09	0.45 ± 0.11*	0.41 ± 0.09	p = 0.002
	Log SDV	0.55 ± 0.32	0.85 ± 0.64	0.80 ± 0.59	NS
	Mean Q	0.79 ± 0.21	1.58 ± 0.32*	0.86 ± 0.18 †	p < 0.001
	Mean V	0.95 ± 0.16	2.8 ± 1.7*	1.2 ± 0.33 †	p = 0.029

Data presented as mean ± SD. Log SDQ = logarithmic standard deviation of blood flow (Q) around Q mean (unit V_A/Q ratio).); Shunt = V_A/Q < 0.005; normal V_A/Q = 0.1 < V_A/Q < 10. Log SDV = logarithmic standard deviation of ventilation (V) around V mean (unit V_A/Q ratio); normal V_A/Q = 0.1 < V_A/Q < 10; high V_A/Q = 10 < V_A/Q < 100; dead space = (inert gas) including apparatus dead space: V_A/Q > 100.
For other explanations see Table 1.

ISSN: 1751-0147