Table 2 Presentation of the Main Coon cat cohort categorised in groups depending on the A31P CMYBP-C genotype.
cMyBP-C p.A31P genotype | P- value mutation negative vs | ||||
|---|---|---|---|---|---|
Homozygous (C/C) | Heterozygous (G/C) | Wild type (G/G) | Homozygous | Heterozygous | |
n, gender distribution | 18 (12 males) | 89 (25 males) | 225 (81 males) | - | - |
Age, y (median, 95% range) | 1.5, 1.0; 11.0 | 2.0, 0.9; 5.9 | 1.7, 1.0; 5.0 | 0.48 | 0.14 |
Weight, kg (median, 95% range) | 5.9, 3.4; 7.0 | 4.6, 3.5; 7.8 | 4.5, 3.4; 7.2 | 0.04 | 0.32 |
IVSd, mm (median, 95% range) | 4.2, 3.2; 9.1 | 3.7, 2.8; 5.5 | 3.7, 2.8; 5.1 | 0.002 | 0.70 |
LVIDd, mm (median, 95% range) | 15.6, 10.2; 18.4 | 15.9, 12.8; 19.0 | 15.6, 12,3; 19.0 | 0.88 | 0.59 |
LVFWd, mm (median, 95% range) | 5.1, 3.6; 11.0 | 3.7, 2.7; 4.8 | 4.0, 2.9; 5.0 | < 0.001 | 0.10 |
IVSs, mm (median, 95% range) | 7.8, 5.0; 11.3 | 6.3, 4.8; 8.1 | 6.4, 4.8; 8.4 | 0.04 | 0.29 |
LVIDs, mm (median, 95% range) | 8.8, 4.0; 13.0 | 9.0, 5.7; 12.6 | 9.0, 6.1; 12.4 | 0.23 | 0.80 |
LVFWs, mm (median, 95% range) | 8.9, 5.5; 13.4 | 6.7, 5.1; 8.3 | 6.7, 5.1; 8.7 | 0.016 | 0.90 |
LA/Ao, (median, 95% range) | 1.1, 0.9; 4.0 | 1.0, 0.9; 1.1 | 1, 0.9; 1.2 | 0.0004 | 0.31 |
% with murmur | 50 | 2 | 4 | ||
% with SAM | 44 | 1 | 0 | ||
% with obliteration | 44 | 4 | 5 | ||
% with hypertrophic papillary muscle | 56 | 9 | 8 | ||
% with increased LA | 22 | 0 | < 1 | ||