Figure 1
From: Morphological and immunohistochemical characterisation of seminomas in Norwegian dogs
Histological appearance of canine seminoma observed in the present study compared with human classical seminoma. (a) Canine seminoma with morphology consistent with human spermatocytic seminoma: anisocytosis, anisokaryosis, numerous mitotic figures (black arrows), degenerate cells (white arrow) and multinucleate cells (arrowhead). HE. Bar, 20 μm. (b) Canine seminoma (same as in (a)). There are scattered, PAS + granules (arrows) in the cytoplasm of many tumour cells. PAS. Bar, 20 μm. (c) Human classical seminoma displaying characteristic monomorphic cells with clear cytoplasm. HE. Bar, 20 μm. (d) Human classical seminoma with numerous, PAS + cytoplasmic granules (arrows). PAS. Bar, 20 μm.