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Figure 1 | Acta Veterinaria Scandinavica

Figure 1

From: Chronic pneumonia in calves after experimental infection with Mycoplasma bovis strain 1067: Characterization of lung pathology, persistence of variable surface protein antigens and local immune response

Figure 1

(A) Gross pathology of caseonecrotic pneumonia; cut surfaces of lung tissue with various sized caseonecrotic lesions (largest area depicted by asterisk). There is marked interlobular fibrosis and suppurative bronchopneumonia in the remaining lung parenchyma. Calf no. 5. Bar = 1 cm; (B) Histopathology of caseonecrotic pneumonia; caseonecrotic lung lesion. The eosinophilic centre (N) is demarcated by inflammatory cells and remnants of necrotic bronchiolar epithelium (arrows). Calf No. 3. H&E. Bar = 184 μm; (C) Immunohistochemical detection of wide spectrum cytokeratin-positive epithelial cells; immunohistochemical staining with antibodies (mAb AE1/AE3) to wide spectrum cytokeratin of the same bronchiole as shown in (B) reveals remnants of bronchiolar epithelial cells (arrows) surrounding the necrotic area (N). At the periphery, demarcating macrophages are present (asterisk). Calf No. 3. ABC method. Bar = 92 μm; (D) Histopathology of obliterative bronchiolitis; obliterative bronchiolitis with vacuolated epithelial cells (arrows) and intraluminal fibroblasts and inflammatory cells. Calf No. 5. H&E. Bar = 46 μm.

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Acta Veterinaria Scandinavica

ISSN: 1751-0147