Chronic pneumonia in calves after experimental infection with Mycoplasma bovis strain 1067: Characterization of lung pathology, persistence of variable surface protein antigens and local immune response

Table 4 Total numbers of peribronchially located CD4⁺ and CD8⁺ T lymphocytes and numbers of immunoglobulin-positive plasma cells

Calf No.¹	CD4⁺ T cells²	CD8⁺ T cells³	IgA⁴	IgG1⁵	IgG2⁶	IgM⁷
1	12.40 ± 3.19^a	1.10 ± 1.72^a	536^a	698^a	305^a	250^a
2	6.60 ± 3.46^a	0.40 ± 0.16^a	634^a	343^a	236^a	195^a
3	15.3 ± 6.16^a	2.10 ± 0.98^a	314^a	421^a	160^a	245^a
4	10.40 ± 2.50^a	1.30 ± 1.30^a	240^a	723^a	167^a	294^a
5	13.30 ± 7.01^a	1.00 ± 1.00^a	530^a	484^a	479^a	293^a
6	8.80 ± 1.76^a	ND^b	760^a	437^a	339^a	409^a
7	11.40 ± 7.26^a	0.20 ± 0.13^a	695^a	257^a	227^a	310^a
8	8.80 ± 7.15^a	1.20 ± 1.12^a	431^a	467^a	297^a	387^a
9	2.00 ± 1.84^a	0.20 ± 0.23^a	528^a	218^a	100^a	225^a
10	10.20 ± 3.88^a	2.00 ± 2.45^a	497^a	300^a	110^a	196^a
11	10.10 ± 5.15^a	0.40 ± 0.04^a	482^a	485^a	262^a	240^a
12	-^b	-^c	464^a	268^a	223^a	345^a

¹ Calves Nos. 1-8 were inoculated with M. bovis, calves Nos. 9-12 were control calves.
^2a,3a Values given as means ± SD of the total numbers of positive cells counted per 1000 μm² of BALT area.
^2b,3c No BALT in tissue sections present.
^3b Not determined.
^4a IgA-positive plasma cells.
^5a IgG1-positive plasma cells.
^6a IgG2-positive plasma cells.
^7a IgM-positive plasma cells.
^4a,5a,6a,7a Values given as means of absolute numbers of positive cells per mm² of BALT.

ISSN: 1751-0147