No | Case | Duration of ivermectin therapy prior to/after trilostane (week) | Duration of milbemycin oxime therapy (week) | Clinical lesions associated with GD after withdrawal of milbemycin oxime (week of withdrawal) | Clinical signs associated with HAC and dosage of trilostane |
---|---|---|---|---|---|
1 | 14 y, M, Pomeranian (2.8 kg) | 9/6 | 5 | Generalized erythema and pyoderma mainly on both flanks (10) | Polydipsia, polyphagia, polyuria, decreased activity, a potbellied appearance, muscular wasting, localized alopecia and chronic pyoderma (franks); |
2.1 mg/kg/day | |||||
2 | 12 y, FS Yorkshire terrier (2.6 kg) | 10/7 | 5 | Generalized erythema and deep pyoderma mainly on back (10) | Polydipsia, polyuria, decreased activity, a potbellied appearance, muscular wasting, generalized alopecia and chronic pyoderma; |
1.9 mg/kg/day | |||||
3 | 12.5 y, FS Maltese terrier (3.8 kg) | 8/6 | 5 | Generalized erythema and deep pododermatitis mainly on face and lateral thighs (8) | Polydipsia, polyphagia, polyuria, decreased activity, panting, a potbellied appearance, muscular wasting, generalized alopecia and chronic pyoderma, calcinosis cutis; |
2.3 mg/kg/day | |||||
4 | 11 y, FS Chihuahua (1.8 kg) | 9/6 | 7 | Generalized erythema and deep pododermatitis (Front two paws) (8) | Polydipsia, polyphagia, polyuria, decreased activity, panting, a potbellied appearance, muscular wasting, generalized alopecia and chronic pyoderma in general, calcinosis cutis; |
3.3/mg/kg/day | |||||
5 | 13 y FS Maltese terrier (5.1 kg) | 6/6 | 7 | Generalized erythema and pyoderma and deep pododermatitis (four paws) (8) | Polydipsia, polyphagia, polyuria, decreased activity, panting, a potbellied appearance, muscular wasting, generalized alopecia and chronic pyoderma in general, concurrent pyonephrosis (one kidney left); |
2.3 mg/kg/day | |||||
6 | 10 y, M Shih Tzu (6.1 kg) | 8/6 | 5 | Generalized erythema and pyoderma and deep pododermatitis (four paws) (9) | Polydipsia, polyuria, decreased activity, panting, a potbellied appearance, generalized alopecia and chronic pyoderma; |
2.0 mg/kg/day | |||||
7 | 9 y, MC Shih Tzu (8 kg) | 8/6 | 5 | Generalized erythema and deep pododermatitis (front two paws) (8) | Polydipsia, polyphagia, polyuria, panting, a potbellied appearance, muscular wasting, localized alopecia and chronic pyoderma (frank); |
1.9 mg/kg/day | |||||
8 | 13 y, MC Yorkshire terrier (5 kg) | 10/7 | 5 | Generalized erythema and pyoderma mainly on back (9) | Polydipsia, polyphagia, polyuria, decreased activity, a potbellied appearance, muscular wasting, generalized alopecia and chronic pyoderma; |
1.7 mg/kg/day | |||||
9 | 11 y, FS Maltese terrier (11.5 kg) | 6/6 | 5 | Generalized erythema and pyoderma mainly on ventral chest (8) | Polydipsia, polyphagia, polyuria, decreased activity, panting, a potbellied appearance, muscular wasting, generalized alopecia and chronic pyoderma; |
1.7/mg/kg/day | |||||
10 | 12.5 y, FS Maltese terrier (4.5 kg) | 6/6 | 7 | Generalized erythema and deep pyoderma mainly on back (8) | Polydipsia, polyuria, decreased activity, panting, a potbellied appearance, muscular wasting, generalized alopecia, chronic pyoderma and concurrent DM; |
1.9 mg/kg/day | |||||
11 | 15 y, FS Shih Tzu (6.2 kg) | 9/6 | 5 | Generalized erythema and pyodermaand deep pododermatitis (two front paws) (8) | Polydipsia, polyuria, decreased activity, panting, a potbellied appearance, muscular wasting in both thighs, generalized alopecia and pyoderma; |
1.8 mg/kg/day | |||||
Period of Ivermectin before/after concomitant trilostane treatment Mean: 8.1/6.2 weeks Median: 8/6 weeks | Period of Milbemycin oxime after concomitant trilostane treatment Mean: 5.5 weeks Median: 5 weeks | Period of non-mitidal treatment after Milbemycin oxime withdrawn Mean: 8.5 weeks Median: 8 weeks |