Myophagocytosis in pig infected with FMDV A24 Cruzeiro (case 1). A large, mononuclear, CD44+ cell (B&D) surrounds an FMDV infected cardiomyocyte. Fragments of FMDV VP1 capsid protein and cardiomyocyte actin are within subcellular structures of the CD44+ cell (presumptive macrophage-lineage; B&D). FMDV A capsid (red; A-D), actin (blue; A-D), CD163 (turquoise; C&D), CD44 (green; B&D). Multichannel immunofluorescence. Scale bars = 10 μm.