Table 1 Median (range) values for the plasma and urine variables in samples collected from six sheep with ketoprofen induced AKI confirming renal impairment and from six control sheep [32]

0 h

case

86 (80–106)

5.3 (3.9-6.9)

17.8 (8.0-21.8)

0.11 (0.09-0.18)

3.2 (1.9-5.0)

0.86 (0.50-1.18)

0.03 (0.02-0.04)

contr

92 (81–113)

4.7 (3.5-5.2)

12.4 (8.9-14.9)

0.14 (0.08-0.38)

3.7 (2.6-7.4)

0.94 (0.56-1.14)

0.03 (0.02-0.04)

2 h

case

89 (82–109)

5.8† (4.5-7.6)

10.9 (3.7-16.6)

0.96† (0.56-1.5)

4.3 (1.9-9.7)

0.86 (0.79-1.38)

0.12*† (0.04-0.26)

contr

89 (79–106)

4.9 (3.6-6.1)

13.4 (10.9-25.4)

0.49† (0.18-1.38)

4.3 (1.6-10.6)

0.81 (0.39-1.98)

0.02 (0.02-0.03)

4 h

case

120*† (100–140)

7.2*† (5.6-8.8)

7.2*† (4.5-10.0)

7.72*† (4.09-19.6)

13.9*† (9.4-42.4)

1.66 (0.49-4.20)

NM

contr

91 (74–101)

4.6 (3.7-5.7)

14.9 (6.3-27.1)

0.78† (0.34-1.77)

5.2 (1.4-13.2)

1.01 (0.37-2.95)

NM

6 h

case

151*† (131–191)

8.8*† (6.6-9.6)

3.9*† (2.2-7.9)

18.0*† (6.69-63.1)

42.3*† (27.7-135.8)

3.02*† (1.27-8.17)

0.73*† (0.17-1.40)

contr

90 (71–102)

4.1 (3.4-5.7)

15.3 (12.7-25.6)

1.41† (0.38-2.67)

5.8 (2.5-18.6)

1.07 (0.56-3.69)

0.02 (0.02-0.04)

8 h

case

184*† (150–208)

9.8*† (7.1-10.4)

2.7*† (1.4-6.5)

27.2*† (3.05-112.9)

98.2*† (16.2-420.8)

6.17*† (2.62-17.53)

NM

contr

88 (74–105)

3.4 (2.8-5.0)

12.8 (6.6-24.8)

1.36† (0.69-3.58)

9.6 (3.0-20.1)

1.34 (0.40-3.35)

NM

24 h

case

390*† (131–414)

20.6*† (14.0-22.3)

2.7† (2.2-3.5)

3.76† (0.97-16.5)

27.4† (8.7-86.3)

2.62 (0.89-16.13)

0.26*† (0.05-0.60)

contr

90 (71–101)

4.1 (2.6-7.2)

9.1 (2.1-20.0)

0.77† (0.23-3.60)

8.5 (4.4-9.9)

1.33(0.78-2.93)

0.04 (0.02-0.15)