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Table 4 Final population pharmacokinetic parameters

From: Clinical and pharmacokinetic evaluation of S-ketamine for intravenous general anaesthesia in horses undergoing field castration

Pk paramaters

S-ketamine

S-norketamine

V1 (mL/kg)

132.7

59.9

Cl1 (mL/kg/min)

36.3

30

V2 (mL/kg)

376.3

 

Cl2 (mL/kg/min)

14.9

 

ClParMet (mL/kg/min)

21.1

 

t1/2 (min)

8.5

8.6

Cltot (mL/kg/min)

44.5

 

Vss (mL/kg)

191.4

 

AUC (μg/min/mL)

56.2

16.2

AUMC (μg/min2/mL)

241.6

272.5

MRT (min)

4.3

16.82

Cmax (μg/mL)

 

0.8

Tmax (min)

 

7.4

  1. V1: Volume of the central compartment; Cl1: Clearance from the central compartment; V2: Volume of the peripheral compartment; Cl2: Clearance from the peripheral compartment; ClParMet: Clearance from S-ketamine to S-norketamine; t1/2: Elimination half-life; Cltot: Total body clearance; Vss: Volume of distribution at steady-state; AUC: Area under the time course curve; AUMC: Area under the moment of the time course curve; MRT: Mean residence time; Cmax: Maximum concentration; Tmax: Time at maximum concentration.