Fig. 4

Teratogenic lesions associated with intrauterine infection with Akabane virus (AKAV). a Exposure of the brain after removal of the dorsal aspect of the skull. The hemispheres are partly collapsed due to severe hydranencephaly. Fluid is oozing out the brain cavities (due to damage to the vulnerable remnants of the cerebrum during opening of the skull) and surrounds the brain. Notice the normal sized cerebellum. Hydranencephaly usually develops in foetuses infected with AKAV between days 79 and 104 in gestation. b Generalised arthrogryposis of the appendicular skeleton, which typically develops in foetuses infected with AKAV between days 103 and 174 in gestation