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Table 2 Physiologic, anaesthetic and blood gas data for the two experimental groups (low blood pressure—LBP and normal blood pressure—NBP) at key study time points

From: The effect of dexmedetomidine on cerebral perfusion and oxygenation in healthy piglets with normal and lowered blood pressure anaesthetized with propofol-remifentanil total intravenous anaesthesia

Group

Pre-caval block (PCB)

Propofol-remifentanil 1 (PR-1)

Propofol-remifentanil 2 (PR-2)

Propofol-remifentanil-dexmedetomidine (PRD)

Reference ranges

LBP

NBP

LBP

NBP

LBP

NBP

LBP

Body temperature (°C)

38.6 (37.5–40.0)

37.9 (37.3–38.9)

38.7 (37.5–39.9)

38.3 (37.7–39.3)

39.7 (38.0–40.9)

38.3 (37.2–39.3)

40 (38.1–40.1)

38.7–39.8 [37]

FIO2 (%)

84 (82–87)

83 (78–85)

85 (82–87)

84 (80–85)

86 (83–87)

84 (79–85)

85 (83–87)

–

Pulse rate (beats/min)

80 (54–104)

67 (57–85)

87a (58–137)

80 (68–85)

114 (67–179)

78 (51–111)

111 (71–153)

70–120 [37]

ETCO2 (mmHg)

45 (41–50)

45 (44–47)

47 (43–48)

47 (46–49)

49 (43–61)

43a (42–45)

44a (38–51)

35–50 mmHg [41]

pH1

7.4 (7.34–7.46)

7.43 (7.38–7.47)

7.41 (7.35–7.46)

7.41 (7.31–7.46)

7.32b (7.25–7.46)

7.46a (7.39–7.49)

7.37a (7.29–7.48)

7.4–7.43[38];7.4–7.53 [39]

pCO2 (mmHg)1

49 (48–56)

51 (48–52)

50 (45–55)

53 (49–60)

56a (45–68)

51 (48–52)

52a (44–55)

41.8–49.1 [38]

pO2 (mmHg)1

443 (432–482)

449 (431–507)

463 (411–487)

452 (433–485)

447 (426–498)

455 (422–497)

480 (434–498)

18.8–39.1 [38]

HCO3 − (mmol/l)

31 (28–34)

33 (30–35)

30 (28–34)

33 (30–37)

29 (25–32)

35 (31–38)

30b (24–33)

24.9–30.3 [38] 22–33 [39]

Base excess (mmol/l)

6 (3–11)

9 (5–12)

5 (3–10)

10 (4–14)

4 (−1– 9)

11 (7–15)

5b (−2–10)

1.3–5.1(+) [38]

Glucose (mmol/l)

4.9 (3.9–5.6)

5.4 (4.8–6.9)

5.5a (4.8–8.0)

7.2 (4.9–8.4)

9.6 (4.4–14.7)

5.2 (3.7–5.9)

6.4 (4.3–9.5)

2.6–6.5 [39]

Lactate (mmol/l)

0.5 (0.4–2.1)

0.9 (0.7–1.0)

0.9a (0.4–2.4)

0.7 (0.3–1.4)

1.2 (0.7–3.0)

0.5 (0.3–0.9)

1.3 (0.5–3.9)

0.5–1.5 [39]; 0.5–5.5 [40]

Total haemoglobin (mmol/l)

4.6 (4.6–5.6)

4.6 (4.6–6.1)

5.0a (4.6–6.1)

4.9 (4.6–6.1)

5.6a (5.0–7.0)

4.7 (4.2–6.1)

5.2 (4.6–6.0)

6.21–9.93 [37]

Haematocrit (%)

24 (24–29)

24 (24–32)

26a (24–32)

26 (24–32)

29a (26–36)

25 (22–32)

27 (24–31)

29.5–45.9 [42]

  1. Median values are shown with range (min–max)
  2. For the LBP group, statistically significant differences were pulse rate (P = 0.02, median increase 10, 95% CI 2; 47), ETCO2 (P = 0.02, median decrease 5 mmHg, 95% CI 2; 11), pH (P = 0.05, median increase 0.04, 95% CI 0.01; 0.08), pCO2 (P = 0.03, median increase 6 mmHg, 95% CI 1; 11, and P = 0.03, median decrease 5 mmHg, 95% CI 3; 9), glucose (P = 0.05, median increase 1.2 mmol/l, 95% CI 0.0; 2.7, and P = 0.02, median increase 3.5 mmol/l, 95% CI 0.8; 7.1), lactate (P = 0.04, median increase 0.2 mmol/l, 95% CI 0.0; 1.0), total haemoglobin (P = 0.05, median increase 0.4 mmol/l, 95% CI 0.0; 0.8 and P = 0.02, median increase 0.5, 95% CI 0.2; 1.2), and haematocrit (P = 0.05, median increase 2%, 95% CI 0; 4, and P = 0.02 (median increase 3%, 95% CI 1; 6). For the NBP group, statistically significant differences were ETCO2 (P = 0.01, median decrease 4 mmHg, 95% CI 2; 5) and pH (P = 0.01, median increase 0.05, 95% CI 0.02; 0.08). Significant intergroup differences were pH (P = 0.03, median difference 0.09, 95% CI 0.01; 0.15), HCO3 − P = 0.03 (median difference 6 mmol/l, 95% CI 2; 9) and base excess (P = 0.03, median difference 7 mmol/l, 95% CI 2; 12)
  3. 1Temperature corrected values
  4. aStatistically significant differences from the previous study time point
  5. bStatistically significant differences from the other experimental group within the same time point