Fig. 1

A schematic pedigree of Alaskan malamute dogs affected by hereditary polyneuropathy. A schematic pedigree of historical Norwegian and recent Scandinavian Alaskan malamute dogs affected by hereditary polyneuropathy, showing that both parents of all affected dogs are descending from one common ancestor. The families of historical dogs have a shaded background in the figure. Genotyped dogs are indicated as homozygous or heterozygous for the NDRG1-mutation, or homozygous wild type (wt/wt). Dogs that are neither affected nor genotyped are classified as either clinically unaffected or with unknown disease status. The mother of a test-mating litter of the historical dogs was inseminated. By accident, one straw of semen from another dog than the one meant to be father was used together with straws from the intended male, which is shown as two fathers for that specific litter in the figure. Black arrow points at common ancestor, born approximately 1955