Expression of microRNAs in cerebrospinal fluid of dogs with central nervous system disease

Table 1 Clinical data for inflammatory condition group (A), neoplastic condition group (B), idiopathic epilepsy group (C), degenerative condition group (D), and other neurological disorders not affecting the CNS group (E)

Case	Signalment			Final diagnosis
Case	Breed	Age (years)	Sex	Final diagnosis
A	Bernese Mountain Dog	1	FN	Steroid-responsive meningitis-arteritis
A	Medium size mixed breed	9	MN	Idiopathic polyradiculoneuritis
A	Bichon Frise	2	FN	Meningoencephalitis of unknown origin
A	Dalmatian	0.5	FE	Steroid-responsive meningitis-arteritis
B	American Bulldog cross	9	ME	Mixed glioma—brain^a
B	Miniature Schnauzer	7	ME	Suspected histiocytic sarcoma—brain^a
B	Flat Coat Retriever	8	MN	Histiocytic sarcoma—lumbar spinal cord^a
B	Boxer	6	FN	Glioma—brain
C	Labrador Retriever	2	FN	Idiopathic epilepsy
C	Collie cross	8	FN	Idiopathic epilepsy
C	Collie	3	MN	Idiopathic epilepsy
C	Staffordshire Bull Terrier cross	7	FN	Idiopathic epilepsy
C	Giant Schnauzer	7	FN	Idiopathic epilepsy
C	Bearded Collie	6	FN	Idiopathic epilepsy
D	German Shepherd Dog	4	MN	Canine degenerative myelopathy—SOD1 homozygous
D	German Shepherd Dog	10	FN	Canine degenerative myelopathy—SOD1 homozygous^a
E	Cavalier King Charles Spaniel	6	FN	Vestibular signs associated with otitis media-interna^b
E	Border Collie	14	FN	Geriatric idiopathic vestibular disease^b
E	Labrador Retriever	12	FE	Geriatric idiopathic vestibular disease^b
E	Border Terrier	9	MN	Iliopsoas sarcoma^a

SOD1: Canine degenerative myelopathy is a progressive neurodegenerative disease associated with the c.118G > A substitution in exon 2 of the canine superoxide dismutase 1 (SOD1) gene in German Shepherd Dogs and other affected canine breeds
FE female entire, FN female neutered, ME male entire, MN male neutered
^a Diagnosis supported by histopathology
^b Diagnosis supported by clinical examination, MRI findings, CSF analysis and cytology

ISSN: 1751-0147