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Table 3 Discriminant plasma metabolites differentiating fasting and postprandial metabolomes significant in mixed model repeated measures analysis, all the included 28 dogs

From: Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs

Metabolite

Fasting

Postprandial

SEb

Mean ± SD (µM)

Hours

Mean ± SD (µM)

P valuea

Alanine

221 ± 50.8

1

249 ± 50.6

< 0.0001

5.94

2

265 ± 48.7

< 0.0001

7.97

3

264 ± 44.4

< 0.0001

9.27

4

241 ± 44.5

0.27

10.2

Arginine

94.1 ± 10.6

1

104 ± 14.0

< 0.0001

1.91

2

106 ± 15.8

< 0.0001

2.51

3

106 ± 16.1

0.0006

2.88

4

101 ± 13.2

0.16

3.12

Glutamine

431 ± 67.5

1

414 ± 49.5

0.04

5.68

2

396 ± 50.2

0.0002

7.75

3

392 ± 42.4

0.0005

9.16

4

389 ± 48.1

0.0007

10.2

Glycine

149 ± 22.7

1

173 ± 27.6

< 0.0001

3.74

2

178 ± 33.5

< 0.0001

5.02

3

177 ± 40.2

< 0.0001

5.85

4

166 ± 32.2

0.06

6.43

Isoleucine

35.3 ± 6.1

1

40.8 ± 5.4

< 0.0001

1.01

2

46.6 ± 6.9

< 0.0001

1.31

3

51.1 ± 6.7

< 0.0001

1.47

4

52.0 ± 6.8

< 0.0001

1.57

Leucine

64.6 ± 9.9

1

73.1 ± 8.9

< 0.0001

1.70

2

83.5 ± 11.6

< 0.0001

2.18

3

90.8 ± 10.6

< 0.0001

2.44

4

92.4 ± 10.7

< 0.0001

2.59

Lysine

82.0 ± 20.0

1

88.3 ± 18.2

0.002

1.88

2

87.9 ± 18.1

0.12

2.56

3

83.8 ± 15.9

0.97

3.02

4

76.2 ± 15.3

0.47

3.37

Ornithine

8.2 ± 3.3

1

11.9 ± 2.3

< 0.0001

0.48

2

14.7 ± 3.9

< 0.0001

0.64

3

15.2 ± 4.4

< 0.0001

0.74

4

14.1 ± 4.1

< 0.0001

0.81

Proline

111 ± 17.6

1

139 ± 20.8

< 0.0001

3.63

2

157 ± 27.3

< 0.0001

4.71

3

163 ± 29.0

< 0.0001

5.32

4

157 ± 25.5

< 0.0001

5.70

Valine

105 ± 14.7

1

117 ± 13.6

< 0.0001

2.41

2

133 ± 16.6

< 0.0001

3.13

3

148 ± 16.3

< 0.0001

3.53

4

153 ± 16.2

< 0.0001

3.78

  1. Mixed model repeated measures analysis with significance level P < 0.05 and Tukey–Kramer adjustment within model. Fasting and postprandial metabolite concentrations (µM) are shown as mean ± standard deviation (SD). Ten metabolites were overall different between time points (glutamine P = 0.0004 the remaining nine P < 0.0001)
  2. aP-values for comparisons between fasting and each postprandial time point, respectively
  3. bStandard error (SE) for comparisons between fasting and postprandial time points