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Fig. 1 | Acta Veterinaria Scandinavica

Fig. 1

From: Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis

Fig. 1

Illustration of the sequential approach that was adopted to estimate the PK/PD parameters. The upper row shows the dexamethasone synovial fluid and plasma disposition model (a) and the lower row the pharmacodynamic model (b) describing the LPS challenge and lameness response (RLL). The post hoc estimates of individual PK parameters were fixed to their post hoc estimate to “drive” the drug-mechanism function (I(Csyn)) acting on production of lameness response induced by the LPS-challenge [25]

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