Horse

Dose (mg)

V_{syn} (mL/kg)

k_{ap} (1/h)

k_{pa} (1/h)

k_{el} (1/h)

V_{c} (mL/kg)

V_{t} (mL/kg)

Cl (mL/kg/h)

Cl_{d} (mL/kg/h)


tv

na

0.2

0.6

0.15

0.010

338

1123

246

495

F

0.01

0.49

0.61

0.15

0.010

279

1135

247

491

C

0.03

0.27

0.61

0.14

0.011

148

1114

253

690

B

0.1

0.26

0.65

0.14

0.013

126

1018

266

778

A

0.3

0.18

0.74

0.15

0.009

85

997

417

598

D

1

0.20

1.06

0.15

0.010

308

1133

446

637

E

3

0.03

1.91

0.15

0.010

230

1263

470

763

 Where tv is the typical value for the population, dose is the amount dexamethasone administered into the joint, V_{syn}, V_{c} and V_{t} are the volume of distribution in the synovial compartment (typical value was fixed to 0.2 mL/kg), the central compartment and the peripheral compartment, respectively. Cl is the plasma clearance and Cl_{d} is the intercompartmental distribution parameter. k_{ap}, k_{pa} and k_{el} are the rate constants from the joint to the plasma, the plasma to the joint and direct elimination from the joint, respectively. Note that shrinkage was high (> 0.3) for k_{ap}, k_{pa} k_{el}, V_{syn} and Cl due to a poor estimate of the random component of the model for these parameters and corresponding post hoc values were shrinked toward their population values