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Table 2 Model typical values (tv) and the individual pharmacokinetic parameter estimates for the horses A–F

From: Disposition and effect of intra-articularly administered dexamethasone on lipopolysaccharide induced equine synovitis

Horse Dose (mg) Vsyn (mL/kg) kap (1/h) kpa (1/h) kel (1/h) Vc (mL/kg) Vt (mL/kg) Cl (mL/kg/h) Cld (mL/kg/h)
tv na 0.2 0.6 0.15 0.010 338 1123 246 495
F 0.01 0.49 0.61 0.15 0.010 279 1135 247 491
C 0.03 0.27 0.61 0.14 0.011 148 1114 253 690
B 0.1 0.26 0.65 0.14 0.013 126 1018 266 778
A 0.3 0.18 0.74 0.15 0.009 85 997 417 598
D 1 0.20 1.06 0.15 0.010 308 1133 446 637
E 3 0.03 1.91 0.15 0.010 230 1263 470 763
  1. Where tv is the typical value for the population, dose is the amount dexamethasone administered into the joint, Vsyn, Vc and Vt are the volume of distribution in the synovial compartment (typical value was fixed to 0.2 mL/kg), the central compartment and the peripheral compartment, respectively. Cl is the plasma clearance and Cld is the inter-compartmental distribution parameter. kap, kpa and kel are the rate constants from the joint to the plasma, the plasma to the joint and direct elimination from the joint, respectively. Note that shrinkage was high (> 0.3) for kap, kpa kel, Vsyn and Cl due to a poor estimate of the random component of the model for these parameters and corresponding post hoc values were shrinked toward their population values