Horse | Dose (mg) | Vsyn (mL/kg) | kap (1/h) | kpa (1/h) | kel (1/h) | Vc (mL/kg) | Vt (mL/kg) | Cl (mL/kg/h) | Cld (mL/kg/h) |
|---|
tv
| na | 0.2 | 0.6 | 0.15 | 0.010 | 338 | 1123 | 246 | 495 |
F | 0.01 | 0.49 | 0.61 | 0.15 | 0.010 | 279 | 1135 | 247 | 491 |
C | 0.03 | 0.27 | 0.61 | 0.14 | 0.011 | 148 | 1114 | 253 | 690 |
B | 0.1 | 0.26 | 0.65 | 0.14 | 0.013 | 126 | 1018 | 266 | 778 |
A | 0.3 | 0.18 | 0.74 | 0.15 | 0.009 | 85 | 997 | 417 | 598 |
D | 1 | 0.20 | 1.06 | 0.15 | 0.010 | 308 | 1133 | 446 | 637 |
E | 3 | 0.03 | 1.91 | 0.15 | 0.010 | 230 | 1263 | 470 | 763 |
- Where tv is the typical value for the population, dose is the amount dexamethasone administered into the joint, Vsyn, Vc and Vt are the volume of distribution in the synovial compartment (typical value was fixed to 0.2 mL/kg), the central compartment and the peripheral compartment, respectively. Cl is the plasma clearance and Cld is the inter-compartmental distribution parameter. kap, kpa and kel are the rate constants from the joint to the plasma, the plasma to the joint and direct elimination from the joint, respectively. Note that shrinkage was high (> 0.3) for kap, kpa kel, Vsyn and Cl due to a poor estimate of the random component of the model for these parameters and corresponding post hoc values were shrinked toward their population values
