Horse

Dose (mg)

IC_{50} (ng/mL)

I
_{
max}

k_{out} (1/h)

A_{LPS1} (R/h)

A_{LPS2} (R/h)

k_{LPS1} (1/h)

k_{LPS2} (1/h)

γ
_{1}

γ
_{2}


tv

na

4.0

0.84

0.44

3.5

48.4

0.04

0.65

3.9

0.8

F

0.01

3.4

0.85

0.39

3.4

41.2

0.07

0.68

2.2

0.6

C

0.03

2.9

0.85

0.59

3.4

43.3

0.06

0.68

1.6

0.6

B

0.1

3.4

0.86

0.35

3.4

40.9

0.05

0.68

4.9

0.5

A

0.3

3.1

0.85

0.39

3.4

47.5

0.007

0.69

12.8

1.5

D

1

3.4

0.84

0.33

3.4

41.7

0.08

0.67

4.0

0.6

E

3

3.9

0.85

0.39

3.4

41.2

0.07

0.68

2.1

0.6

 Where tv is the typical value for the population, dose is the amount dexamethasone administered into the joint, IC_{50}, I_{max} and k_{out} are the potency value, the efficacy value (with a maximal possible value of 1) and fractional elimination rate of the response, respectively. A_{LPS1}, A_{LPS2}, k_{LPS1}, k_{LPS2}, γ_{1} and γ_{2} are maximal input rates, the rate constant controlling the time development of the challenge function and exponents shaping (amplifying) the response to the LPSchallenge, respectively. Note that shrinkage was high (> 0.3) for IC_{50}, I_{max}, A_{LPS1}, A_{LPS2} and k_{LPS2} due to a poor estimate of the random component of the model for these parameters and corresponding post hoc values were shrinked toward their population values