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Fig. 1 | Acta Veterinaria Scandinavica

Fig. 1

From: Towards improvements in foot-and-mouth disease vaccine performance

Fig. 1

Production and processing of FMDV proteins. The FMDV RNA (top) encodes a large polyprotein that is processed, during and after translation, to a collection of precursors (P1-2A, P2 and P3) and mature products largely through the action of the 3C protease. Many other processing intermediates are made but are not shown. The cleavage of the myristoylated VP0 to VP4 and VP2 occurs during particle assembly. The myristoylation of the N-terminal glycine of the capsid precursor P1-2A is achieved by a host cell system. The two forms of the Leader protease (Lab and Lb) cleave themselves from the capsid precursor. The 5′ UTR includes extensive secondary structure, one region is the internal ribosome entry site (IRES) required for initiation of protein synthesis on the viral RNA

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