Exposure to benzylpenicillin after different dosage regimens in growing pigs

Table 1 Dosing regimens for three benzylpenicillin formulations used to determine the exposure profiles in grower pigs

Study part	n pigs	Medicinal product	Admin route	Loading dose (mg/kg)	Maintenance dose (mg/kg)	Dosing interval	Treatment duration (days)
I	3	Bensylpenicillin Meda	IV	–	10	Single dose	Na*
I	3	Bensylpenicillin Meda	IV	–	20	Single dose	Na*
I	6	Ethacilin vet	IM	–	20	Single dose	Na*
I	6	Ultrapen vet	IM	–	30	Single dose	Na*
II	6	Ethacilin vet	IM	–	20	Every 12 h	3
II	6	Ethacilin vet	IM	–	20	Every 24 h	3
II	6	Ethacilin vet	IM	–	30	Every 24 h	3
II	6	Ultrapen vet	IM	–	30	Every 24 h	3
III	6	Ethacilin vet	IM	–	30	Every 12 h	5
III	6	Ultrapen vet	IM	–	30	Every 24 h	5
III	6	Ultrapen vet	IM	–	30	Every 24 h	3
III	6	Ultrapen vet	IM	60	30	Every 24 h	3
III	6	Ultrapen vet	IM	30^a	30	Every 24 h	3.5

Table 1. Dosing regimens for three benzylpenicillin formulations used to determine the exposure profiles in healthy pigs and pigs inoculated intranasally with an Actinobacillus pleuropneumoniae serotype 2 strain. The three formulations used were: Ethacilin vet (ETH) (Intervet AB, Sollentuna, Sweden) containing 300 mg/ml procaine benzylpenicillin in an aqueous suspension; Ultrapen vet (UPA) (N-vet, Uppsala, Sweden), containing 300 mg/ml procaine benzylpenicillin in an oily suspension, and Bensylpenicillin Meda (BPM) containing potassium benzylpenicillin (Meda AB, Solna, Sweden)
^aEthacilin vet 30 mg/kg was administered twelve h before first Ultrapen vet administration
*Not applicable

ISSN: 1751-0147