Fig. 5
From: Early immunohistochemical detection of pulmonary micrometastases in dogs with osteosarcoma
Section of lung tissue from a dog with osteosarcoma without macroscopic metastases (case 5) showing immunolabeling (red staining) with tumour protein-3 (TP-3) of a single cell. Based on staining pattern and intensity, as well as cytoplasmatic and nuclear morphology, this cell may represent a tumour cell. Snap frozen tissue, immunoperoxidase stain, TP-3, AEC chromogen and haematoxylin counterstain, 400 × magnification