Fig. 4
From: Undifferentiated laryngeal carcinoma with hyaline bodies in a cat
Histological and immunohistochemical features of the neoplasm: A neoplastic cells are arranged in densely cellular, partially encapsulated nodules and are supported by a thick fibrovascular stroma that subdivides the nodules in variably sized packets (HE stain ×40). B Higher magnification shows highly pleomorphic neoplastic cells multifocally presenting one large, brightly eosinophilic perinuclear body (asterisk) (HE stain ×400). C Immunohistochemistry for pancytokeratin, neoplastic cells diffusely show intense cytoplasmic immunolabelling for pancytokeratin (×100). D Immunocytochemistry for vimentin, fibrovascular stromal cells as well as tumour infiltrating inflammatory cells (lymphocytes and macrophages) diffusely show intense cytoplasmic immunolabelling for vimentin (×100)