|
Variables
|
Groups
|
Moments
|
|---|
|
M1
|
M2
|
M3
|
M4
|
M5
|
M6
|
M7
|
|---|
|
HR (bpm)
|
CG
|
150 ± 20
|
160 ± 23
|
202 ± 24
|
195 ± 23
|
183 ± 22
|
171 ± 24
|
169 ± 20
|
| |
MG
|
162 ± 22
|
155 ± 20
|
181 ± 20#
|
188 ± 12#
|
177 ± 19
|
172 ± 21
|
180 ± 17#
|
| |
LG
|
146 ± 23
|
157 ± 25
|
176 ± 28
|
178 ± 30
|
167 ± 25
|
165 ± 28
|
164 ± 27
|
| |
KG
|
161 ± 24
|
148 ± 17
|
173 ± 16
|
177 ± 16
|
171 ± 18
|
169 ± 20
|
165 ± 20
|
| |
LMG
|
136 ± 9
|
127 ± 7*
|
161 ± 17*
|
170 ± 20
|
158 ± 17
|
151 ± 13
|
133 ± 16*#
|
| |
KMG
|
139 ± 15
|
138 ± 21
|
159 ± 26*#
|
164 ± 18*#
|
156 ± 21*
|
149 ± 17
|
133 ± 13*
|
| |
LKMG
|
155 ± 23
|
153 ± 25
|
174 ± 16*
|
178 ± 18
|
174 ± 12
|
165 ± 17
|
154 ± 11
|
|
SBP (mmHg)
|
CG
|
72.2 ± 14.7
|
93.8 ± 31.6
|
127.2 ± 47.5
|
133.5 ± 39.7
|
113.0 ± 32.1
|
107.1 ± 31.9
|
108.5 ± 17.8
|
| |
MG
|
81.5 ± 8.7
|
96.1 ± 36.7
|
114.6 ± 25.0
|
109 ± 19.1
|
97.1 ± 28.1
|
91.6 ± 14.9
|
94.1 ± 17.2
|
| |
LG
|
55.0 ± 11.9
|
71.2 ± 13.0
|
96.5 ± 32.7
|
92.5 ± 37.0
|
71.0 ± 19.4
|
81.75 ± 16.1
|
80.7 ± 16.2
|
| |
KG
|
71.7 ± 15.6
|
90.0 ± 32.2
|
110.7 ± 32.4
|
108.5 ± 33.4
|
96.2 ± 42.5
|
95.7 ± 25.6
|
104.2 ± 32.6
|
| |
LMG
|
67.0 ± 12.7
|
87.0 ± 27.5
|
113.7 ± 52.4
|
119.2 ± 54.1
|
101.2 ± 46.3
|
96.0 ± 41.5
|
87.5 ± 40.4
|
| |
KMG
|
66.8 ± 16.9
|
83.3 ± 34.9
|
109.1 ± 53.4
|
105.3 ± 43.0
|
94.8 ± 52.9
|
91.1 ± 47.4
|
96.0 ± 46.7
|
| |
LKMG
|
66.0 ± 7.0
|
85.0 ± 22.7
|
99.5 ± 19.9
|
101.0 ± 28.9
|
90.0 ± 26.4
|
93.2 ± 24.1
|
90.7 ± 20.2
|
|
RR (mpm)
|
CG
|
25 ± 6
|
27 ± 10
|
29 ± 10
|
31 ± 10
|
29 ± 11
|
26 ± 10
|
25 ± 7
|
| |
MG
|
39 ± 10#
|
30 ± 9#
|
32 ± 11#
|
33 ± 10#
|
28 ± 12#
|
29 ± 11#
|
27 ± 13#
|
| |
LG
|
30 ± 4•
|
31 ± 5•
|
30 ± 5•
|
28 ± 8
|
26 ± 8
|
25 ± 8
|
27 ± 7
|
| |
KG
|
18 ± 9#•
|
18 ± 7#•
|
19 ± 8#•
|
18 ± 8A
|
18 ± 9
|
17 ± 8
|
20 ± 10
|
| |
LMG
|
24 ± 8
|
16 ± 5
|
20 ± 7
|
18 ± 7A
|
18 ± 8
|
16 ± 7
|
16 ± 6
|
| |
KMG
|
23 ± 8#
|
20 ± 9•
|
19 ± 10*#•
|
18 ± 7*#•
|
15 ± 7*#•
|
14 ± 9*#•
|
12 ± 6*#•
|
| |
LKMG
|
22 ± 10#
|
16 ± 8*#•
|
20 ± 9#•
|
19 ± 8*#•
|
19 ± 12
|
18 ± 12
|
18 ± 9
|
|
SpO2 (%)
|
CG
|
99.0 ± 1.6
|
99.1 ± 1.7
|
99.7 ± 0.4
|
99.2 ± 0.7
|
99.5 ± 0.5
|
99.6 ± 0.5
|
99.6 ± 0.5
|
| |
MG
|
96.7 ± 1.6
|
98.2 ± 1.8
|
98.6 ± 1.3
|
98.2 ± 1.2
|
98.2 ± 1.3
|
98.2 ± 2.0
|
98.5 ± 2.0
|
| |
LG
|
99 ± 1.3
|
99 ± 1.0
|
97.8 ± 2.2
|
97.5 ± 2.6
|
98.6 ± 1.1
|
98.6 ± 1.5
|
99 ± 0.7
|
| |
KG
|
99.5 ± 0.5
|
99.2 ± 1.1
|
99.2 ± 0.4
|
98.8 ± 0.9
|
99.3 ± 0.5
|
98.7 ± 1.0
|
99.1 ± 0.8
|
| |
LMG
|
99.3 ± 0.7
|
99.2 ± 1.1
|
98.7 ± 1.7
|
98.2 ± 2.1
|
98.7 ± 1.9
|
99.2 ± 0.7
|
99.3 ± 1.0
|
| |
KMG
|
99.2 ± 1.0
|
99.1 ± 0.8
|
98.3 ± 1.6
|
99.1 ± 0.8
|
98.7 ± 0.8
|
98.8 ± 0.9
|
99 ± 0.5
|
| |
LKMG
|
99.5 ± 0.5
|
99.6 ± 0.5
|
99.2 ± 0.8
|
99.5 ± 0.7
|
99.2 ± 0.8
|
99.6 ± 0.7
|
99.6 ± 0.7
|
|
Etiso (V%)
|
CG
|
1.4 ± 0.2
|
1.4 ± 0.1
|
1.4 ± 0.2
|
1.4 ± 0.1
|
1.4 ± 0.4
|
1.2 ± 0.2
|
0.7 ± 0.2
|
| |
MG
|
0.8 ± 0.1
|
1.3 ± 0.4
|
1.4 ± 0.6
|
1.6 ± 0.2
|
1.7 ± 0.2
|
1.6 ± 0.2
|
0.9 ± 0.4
|
| |
LG
|
1.4 ± 0.2
|
1.4 ± 0.3
|
1.3 ± 0.1
|
1.3 ± 0.2
|
1.2 ± 0.1
|
1.1 ± 0.1
|
1.0 ± 0.2
|
| |
KG
|
1.2 ± 0.1
|
1.2 ± 1.1
|
1.3 ± 0.1
|
1.3 ± 0.1
|
1.3 ± 0.2
|
1.2 ± 0.2
|
1.0 ± 0.2
|
| |
LMG
|
1.4 ± 0.1
|
1.3 ± 0.1
|
1.3 ± 0.07
|
1.4 ± 0.1
|
1.3 ± 0.08
|
1.3 ± 0.1
|
1.3 ± 0.1
|
| |
KMG
|
1.4 ± 0.2
|
1.4 ± 0.1
|
1.2 ± 0.1
|
1.3 ± 0.1
|
1.3 ± 0.1
|
1.3 ± 1.09
|
1.2 ± 0.1
|
| |
LKMG
|
1.4 ± 0.2
|
1.2 ± 0.1
|
1.2 ± 0.1
|
1.2 ± 0.1
|
1.2 ± 0.2
|
1.1 ± 0.1
|
0.9 ± 0.2
|
|
ETCO2
|
CG
|
33.1 ± 8.6
|
34.6 ± 8.9
|
34.6 ± 6.6
|
35 ± 6.6
|
35.8 ± 6.8
|
35.3 ± 6.8
|
34.6 ± 7.1
|
| |
MG
|
33.9 ± 3.8
|
37.4 ± 5.7
|
38.4 ± 6.2
|
38.4 ± 5.6
|
38.5 ± 5.4
|
39.8 ± 5.8
|
40.3 ± 5.7
|
| |
LG
|
26 ± 7.7
|
28.8 ± 7.7
|
27.8 ± 8.7
|
26.9 ± 9.7
|
27.1 ± 10
|
29.5 ± 10.3
|
29.1 ± 11.7
|
| |
KG
|
34.5 ± 6.2
|
35.6 ± 8.6
|
33.6 ± 9.9
|
30.6 ± 9.7
|
31.8 ± 7.9
|
32.8 ± 7.9
|
31.3 ± 8.2
|
| |
LMG
|
27.5 ± 4.7
|
30.5 ± 8.8
|
31 ± 9.3
|
29.7 ± 8.9
|
30.5 ± 8.6
|
30.9 ± 9.1
|
30.6 ± 9.8
|
| |
KMG
|
27.7 ± 10.2
|
29.5 ± 8.3
|
32.8 ± 9.9
|
34.6 ± 11.6
|
34.1 ± 9.5
|
34.4 ± 9.2
|
34.2 ± 9.8
|
| |
LKMG
|
32.5 ± 9.3
|
34.2 ± 8.9
|
37 ± 10.1
|
37.8 ± 10.2
|
36.3 ± 9.3
|
36.4 ± 10.4
|
36.3 ± 8.8
|
|
T (°C)
|
CG
|
37.6 ± 0.8
|
37.6 ± 0.5
|
36.9 ± 0.6
|
36.6 ± 0.8
|
36.5 ± 0.8
|
37.0 ± 0.6
|
37.0 ± 0.7
|
| |
MG
|
37.8 ± 0.9
|
38.0 ± 0.6
|
37.9 ± 0.5
|
37.8 ± 0.5
|
37.7 ± 0.5
|
37.7 ± 0.5
|
37.7 ± 0.6
|
| |
LG
|
37.3 ± 0.4
|
37.1 ± 0.4
|
36.9 ± 0.4
|
36.7 ± 0.4
|
36.4 ± 0.5
|
36.2 ± 0.4
|
36.7 ± 0.5
|
| |
KG
|
37.7 ± 0.4
|
37.4 ± 0.4
|
37.2 ± 0.4
|
36.8 ± 0.4
|
36.3 ± 0.6
|
36.3 ± 0.4
|
36.0 ± 0.3
|
| |
LMG
|
37.0 ± 0.8
|
36.8 ± 0.7
|
36.6 ± 0.7
|
36.4 ± 0.8
|
36.2 ± 0.8
|
36.1 ± 0.9
|
35.8 ± 0.9
|
| |
KMG
|
37.2 ± 0.5
|
37.0 ± 0.5
|
36.9 ± 0.6
|
36.5 ± 0.6
|
36.5 ± 0.6
|
36.4 ± 0.4
|
35.9 ± 0.4
|
| |
LKMG
|
37.7 ± 0.5
|
37.4 ± 0.4
|
37.2 ± 0.4
|
36.9 ± 0.4
|
36.6 ± 0.5
|
36.2 ± 0.4
|
35.8 ± 0.5
|
- CG control group; MG maropitant group; LG lidocaine group; LMG lidocaine and maropitant group; KG ketamine group; KMG ketamine and maropitant group; LKMG lidocaine, ketamine, and maropitant group. T esophageal temperature; RR respiratory rate; HR heart rate; SpO2 oxygen saturation; Etiso expired isoflurane concentration; EtCO2 partial pressure of carbon dioxide at the end of expiration; SBP systolic blood pressure
- *Significant difference relative to CG
- #Significant difference between MG and treatment groups
- •Significant difference between LG and treatment groups. bmp beats per minute; mpm, movement per minute. M1, preoperatively; M2, after incision of the linea alba; M3, after right pedicle clamping; M4, after left pedicle clamping; M5, after ligation of the uterus body; M6, suture of the abdominal muscles; and M7, at the end of the surgery
