Fig. 1

Flow diagram of study selection according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). Study inclusion criteria: (a) peer-reviewed research reports; (b) original data reported in the research paper; (c) use of immunomodulatory and immunosuppressive drug protocols in the management of canine ITP; (d) and reporting outcomes and adverse events according to the used protocol with drug name and dosage range; (e) groups of dogs with ITP with a mean or median platelet count below 50,000/µL with exclusion of other causes of thrombocytopenia using history, physical examination, blood samples, coagulation panel testing, serology and/or polymerase chain reaction and diagnostic imaging