Immunomodulatory and immunosuppressive drug protocols in the treatment of canine primary immune thrombocytopenia, a scoping review

Table 2 Grading of study subject enrollment

Diagnostic criteria	Grade
Diagnostic criteria	Strongly supportive	Supportive	Uncertain
1) Initial verified automated platelet count < 50,000/µL in all animals	Yes	Yes	Yes	No
2) Exclusion of underlying diseases by hematologic and biochemical blood samples, urinalysis, coagulation panel testing, serology and/or PCR for infectious disease and diagnostic imaging of the thorax and abdomen in all animals	Yes	Yes	No	N/A
3) Detection of platelet autoantibodies and/or exclusion of underlying disease by bone marrow sampling in all animals	Yes	No	N/A	N/A

Quality of subject enrollment in studies graded as strongly supportive, supportive, or uncertain for building evidence for a diagnosis of canine primary Immune thrombocytopenia. The table was based on diagnostic criteria suggested by LeVine and Brooks [3], Heseltine and Carr [4] N/A not applicable, PCR polymerase chain reaction

ISSN: 1751-0147