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Table 1 Multi-agent short-term chemotherapy protocol used for the treatment of lymphoma in 144 dogs

From: Efficacy and tolerability of a 12-week combination chemotherapy followed by lomustine consolidation treatment in canine B- and T-cell lymphoma

  

Week

 

Substance

Dose

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

L-asparaginase

400 IU/kg SC

•

                   

Vincristine

0,7 mg/m2 IV

•

  

•

  

•

  

•

          

Cyclophosphamide

250 mg/m2 PO/IV

 

•

  

•

  

•

  

•

         

Doxorubicina

30 mg/m2 IV*

  

•

  

•

  

•

  

•

        

Lomustineb

70 mg/m2 PO

             

•

  

•

  

•

Prednisolone

40 mg/m2 PO × 3 days

30 mg/m2 PO × 3 days

•

                   
 

20 mg/m2 PO × 3 days

10 mg/m2 PO × 3 days

 

•

                  
  1. aPrior treatment with dexamethasone or prednisolone; dogs < 15 kg: 1 mg/kg
  2. bOnly if CR after 12 weeks
  3. IV* intravenous infusion over 30 min
  4. •, drug administered