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Table 1 Summarized study design and detailed information on implemented animals

From: Buprenorphine in rats: potent analgesic or trigger for fatal side effects?

Study

Strain

Sex

Age

Body weight

n

Surgical procedure

Follow-up

1

LEW/NHanZtma

Male

> 16 week

410.8 ± 8.3 g

6

intervertebral disc puncture

6 week

2

Crl:CD (SD)b

Male

> 16 week

547.6 ± 43.7 g

8

intramedullary pin insertion

3 week

  1. aCentral Animal Facility, Hannover Medical School, Germany
  2. bCharles River Laboratories, Sulzfeld, Germany