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Table 2 Multimodal analgesic regime for both studies summarizing the pharmaceutics used and respective application time points

From: Buprenorphine in rats: potent analgesic or trigger for fatal side effects?

 

Day of surgery

1st day post operative

2nd–5th day post operative

Pre-emptive

4–8 h post surgery

12 h post surgery

Morning

Middle of day

At night

Morning

LEW/NHanZtm (study 1)

Car, Bup, LA

Bup

–

Car

–

–

Car

Crl:CD(SD) (study 2)

Car, Bup, LA

Bup

Bup

Car, Bup

Bup

Bup

Car

  1. The multimodal analgesic regime included the non-steroidal antiphlogistic drug Carprofen (Car, 5 mg/kg s.c.), the opioid Buprenorphine (Bup, 0.05 mg/kg s.c.) and a local anesthetic (LA, lidocaine hydrochloride 2%)
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Acta Veterinaria Scandinavica

ISSN: 1751-0147