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The Premature Newborn Calf: How to Use Steroids to Improve Survival?

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Acta Veterinaria Scandinavica200344(Suppl 1):P102

https://doi.org/10.1186/1751-0147-44-S1-P102

Published: 31 March 2003

Keywords

  • Glucocorticoid
  • Lactase
  • Pregnant Mother
  • Premature Neonate
  • Premature Delivery

In all farm animals, premature birth may occur spontaneously or is required in certain states of acute disease for the pregnant mother or its fetus. Under such circumstances, it is crucial to be able to maximize the chances of survival for the neonate. Prenatal organ maturation is known to be stimulated by glucocorticoids and maternal dexamethasone treatment is used for both humans and cattle prior to premature delivery, albeit with variable success. We tested the hypothesis that an ACTH-stimulated increase in fetal glucocorticoid secretion is more effective in stimulating fetal organ maturation than treatment of the pregnant mother with synthetic glucocorticoids. At 248 d gestation (term = 275 d), intravascular catheters were implanted into 13 calf fetuses. After 4–5 days, ACTH-treated calves (250 mg ACTH1–24 4 times daily, n = 6) and control calves (n = 7) were exposed to 20 h of maternal dexamethasone treatment (DEX, 25 mg, i.m.) after which all calves were delivered by caesarean section. 24 h after birth the two groups of premature calves (ACTH+DEX and DEX alone) were killed and compared with a group of 24 hold control calves delivered at full term (TERM).

At 2 h after birth, blood acidity, oxygen and glucose values were all improved in the ACTH+DEX group (Table, * P < 0.05 relative to the DEX group), and the values were similar to those for TERM calves. Increases also occurred in the activities of lactase and 3 peptidases (ApN, ApA, DPP IV) as measured in the proximal small intestine. Finally, rectal temperature over the first 15 h after birth was higher in the ACTH+DEX than in the DEX group (Table). We conclude that prenatal ACTH treatment enhances maturation of the lungs and gut, and it improves glucose homeostasis and thermoregulation in premature neonates born by DEX-treated mothers. A pulsatile pattern of fetal glucocorticoid secretion over a longer period (in response to ACTH-treatment) is more effective in stimulating prenatal organ development than a short-term exposure to pharmacological levels of glucocorticoids administered via the pregnant mother. This method might prove useful to enhance the survival characteristics of particularly valuable newborns subjected to premature delivery.

Table 1

 

DEX

ACTH+DEX

TERM

Blood acidity (pH)

7.22 ± 0.02

7.32 ± 0.02*

7.32 ± 0.01

Blood oxygen (vol%)

3.1 ± 0.8

5.6 ± 0.5*

7.2 ± 1.2

Blood glucose (mM)

1.7 ± 0.3

4.9 ± 0.8*

4.2 ± 0.4

Intestinal lactase (U/g)

23 ± 2

31 ± 2*

33 ± 4

Intestinal ApA (U/g)

0.7 ± 0.1

1.2 ± 0.1*

0.9 ± 0.1

Intestinal DPP IV (U/g)

4.3 ± 0.3

5.6 ± 0.5*

5.4 ± 0.4

Rectal temperature (°C)

37.7 ± 0.1

38.2 ± 0.1*

38.6 ± 0.2

Authors’ Affiliations

(1)
Animal Nutrition and Reproduction, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark

Copyright

© The Author(s); licensee BioMed Central Ltd. 2003

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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