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Amoxicillin Plasma Concentrations After per Oral Application in Newly Weaned Pigs – Effects of Escherichia coli O149,F4 Associated Diarrhoea
© The Author(s); licensee BioMed Central Ltd. 2003
Published: 31 March 2003
The presence of a pathological condition often causes a change in tissue permeability and blood supply. Penetration of an antibiotic into an organ is dependent on those two factors. It is therefore interesting to test if a pathological condition is altering the absorption of an antibiotic into the diseased organ. In this study it was tested if the absorption of Amoxicillin from the alimentary tract could be altered by an Escherichia coli O149,F4 associated diarrhoea.
Twenty-four healthy 4 weeks old newly weaned pigs where used. 14 were inoculated with 1010 cfu of a pathogen O149,F4 strain and responded with a watery diarrhoea 12–16 hrs. later. Having diarrhoea the pigs were treated through a gastric tube with an Amoxicillin trihydrate solution to achieve a dosis of 20 mg pr. kg. bdwgt. A control group of 10 pigs without any signs of diarrhoea was treated as well. Blood samples where taken at 0, 30, 60, 90, 120 min. and 3,6,12 and 24 hrs after medication. The concentration of Amoxicillin in plasma where analysed by a high performance liquid chromatography.
Preliminary data shows a difference in Amoxicillin plasma concentration between the diarrhoeic and control group.
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