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Table 2 Tissues sampled at necropsy

From: Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model

Tissue

Weighed at necropsy

Tissue

Weighed at necropsy

Adrenal glands

Yes

Muscle-skeletal

 

Aorta (thoracic)

 

Nerve-sciatic

 

Bone and bone marrow (sternum)

 

Optic nervesa

 

Brain

Yes

Ovaries

Yes

Brown fat deposita

Yes

Pancreas

 

Cervix

 

Parathyroid glandsb

 

Epididymides

 

Pituitary gland

 

Epididymal fat deposit

Yes

Prostate gland-ventral

Yes

Oesophagusa

 

Retriperitoneal fat deposit

Yes

Eyes

 

Salivary gland-parotid

 

Femur/femoro-tibial jointa

 

Salivary gland-submaxillary/lingual

 

Harderian glanda

 

Seminal vesicles

 

Heart

Yes

Skin

 

Intestine-duodenum

 

Spleena

Yes

Intestine-jejunum

 

Spinal cord-lumbar and cervical

 

Intestine-ileum

 

Stomach

 

Intestine-colon

 

Testes

Yes

Intestine-caecum

 

Thymus

Yes

Intestine-rectum

 

Thyroid glandsb

 

Kidneys

Yes

Tongue

 

Liver with gallbladder

Yes

Trachea

 

Lungs

Yes

Urinary bladder

 

Lymph node-mandibular

 

Uterus

Yes

Lymph node-mesenterica

 

Vagina

 
  1. a/Tissue lost during processing in 1–2 animals and was not evaluated histologically.
  2. b/Tissue lost during processing in all females but one per genotype. The tissue was present on slides from all male mice.