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Table 4 A comparison of absolute tissue weights between CYP2C18&19 transgenic and wild-type mice

From: Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model

 

Tissue

Wt

Tg

Wt

Tg

Body (g)

22.3 ± 1.5

22.2 ± 1.3

21.4 ± 0.5

21.0 ± 0.6

Brain (mg)

446 ± 11.4

427 ± 16.6*

472 ± 9.93

444 ± 11.9***

Heart (mg)

130 ± 7.39

149 ± 8.06***

139 ± 6.80

139 ± 6.05

Lung (mg)

148 ± 15.4

145 ± 5.61

159 ± 12.8

157 ± 18.9

Liver (mg)

1286 ± 76.2

1267 ± 102

1325 ± 89.7

1271 ± 54.2

Kidney (mg)

291 ± 18.9

286 ± 18.8

328 ± 9.51

315 ± 12.9

Adrenal glands (mg)

9.83 ± 3.25

5.83 ± 1.47*

9.33 ± 2.42

7.67 ± 2.16

Spleen (mg)

64.2 ± 7.41

61.0 ± 10.6

88.8 ± 3.49

75.0 ± 6.75***

Thymus (mg)

41.2 ± 7.31

37.7 ± 13.2

60.5 ± 7.45

68.0 ± 11.1

Retriperitoneal fat (mg)

69.7 ± 25.9

61.5 ± 8.07

25.8 ± 11.5

26.3 ± 7.61

Brown fat (mg)

95.0 ± 11.0

48.2 ± 17.9***

66.3 ± 13.5

60.2 ± 12.3

Testes (mg)

209 ± 19.3

210 ± 12.1

  

Prostate (mg)

39.3 ± 12.5

49.2 ± 9.11

  

Epididymal fat (mg)

306 ± 80.0

287 ± 37.0

  

Uterus (mg)

  

89.5 ± 43.0

112 ± 47.0

Ovaries (mg)

  

10.8 ± 6.68

13.3 ± 6.35

  1. The table shows the average absolute tissue weights for each group +/- standard deviations. The statistical comparisons were performed as described in materials and methods. *p ≤ 0.05, ***p ≤ 0.001. wt: wild-type C57BL/6 mice, Tg: hemizygous transgenic mice containing human CYP2C18&19.