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Table 5 Comparisons of haematology and blood chemistry parameters between genotypes of both sexes

From: Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model

Haematology parameter

Blood chemistry parameter

 

Wt

Tg

Wt

Tg

 

Wt

Tg

Wt

Tg

RBC (*1012/L)

8.89 ± 0.213

8.72 ± 0.200

9.78 ± 0.496

9.54 ± 0.286

GLU (mmol/L)

12.2 ± 0.708

13.9 ± 0.88**

15.3 ± 0.97

14.0 ± 1.33

HGB (g/L)

136 ± 1.51

134 ± 1.97

148 ± 8.80

146 ± 4.90

UREA (mmol/L)

7.10 ± 1.58

6.62 ± 1.20

8.58 ± 1.16

8.03 ± 1.33

Hct (%)

43.0 ± 0.894

42.3 ± 0.816

48.0 ± 1.79

47.3 ± 1.21

TP (g/L)

49.2 ± 1.47

48.2 ± 0.75

46.3 ± 1.21

45.7 ± 1.21

MCV (fL)

48.5 ± 1.18

48.7 ± 0.853

49.2 ± 0.809

49.6 ± 0.501

ALB (g/L)

28.0 ± 1.27

27.5 ± 0.548

29.8 ± 0.983

29.5 ± 1.23

MCH (pg)

15.3 ± 0.273

15.4 ± 0.303

15.1 ± 0.293

15.3 ± 0.341

A/G ratio

1.33 ± 0.121

1.33 ± 0.0516

1.80 ± 0.0632

1.85 ± 0.176

MCHC (g/L)

316 ± 4.50

316 ± 4.41

307 ± 8.31

308 ± 6.05

Na (mmol/L)

148 ± 1.03

147 ± 1.38

146 ± 0.516

147 ± 0.837

PLT (*1012/L)

1.18 ± 0.0394

1.18 ± 0.0299

1.04 ± 0.0714

1.07 ± 0.0659

K (mmol/L)

4.42 ± 0.475

4.32 ± 0.313

3.90 ± 0.329

3.83 ± 0.344

WBC (*109/L)

5.21 ± 1.95

4.37 ± 1.05

2.84 ± 1.28

2.32 ± 0.792

ALT (U/L)

79.2 ± 25.4

63.2 ± 18.9

60.3 ± 18.3

45.0 ± 3.35

Neutr (*106/L)

823 ± 752

470 ± 220

597 ± 646

483 ± 402

AST (U/L)

108 ± 62.1

77.0 ± 18.9

110 ± 58.5

93.5 ± 34.2

Lymp (*109/L)

3.99 ± 1.46

3.65 ± 0.975

2.04 ± 0.972

1.71 ± 0.589

ALP (U/L)

111 ± 8.98

113 ± 11.3

122 ± 13.6

134 ± 16.2

Mono (*106/L)

260 ± 237

86.7 ± 24.2

137 ± 95.8

66.7 ± 30.1

TBil (μmol/L)

7.66 ± 1.97

6.83 ± 1.33

11.7 ± 3.33

10.2 ± 1.72

Eosn (*106/L)

107 ± 35.0

127 ± 62.8

63.3 ± 55.7

46.7 ± 35.0

Crea (μmol/L)

8.33 ± 1.86

8.50 ± 1.52

7.83 ± 1.47

7.00 ± 0.894

Baso (*106/L)

6.67 ± 10.3

3.33 ± 8.16

10.0 ± 16.7

0 ± 0

Ca (mmol/L)

2.50 ± 0.0565

2.50 ± 0.0446

2.37 ± 0.0681

2.34 ± 0.0186

LUC (*106/L)

30.0 ± 21.0

30.0 ± 11.0

6.67 ± 10.3

0 ± 0

Chol (mmol/L)

2.42 ± 0.117

2.43 ± 0.163

1.70 ± 0.179

1.67 ± 0.197

Reti (*109/L)

283 ± 27.5

288 ± 15.1

271 ± 36.7

295 ± 30.7

TG (μmol/L)

795 ± 327

848 ± 372

555 ± 50.9

408 ± 83.3**

RDV (%)

12.6 ± 0.147

12.6 ± 0.261

12.9 ± 0.388

12.6 ± 0.210

     
  1. The table shows the average haematology and blood chemistry values for each group +/- standard deviations. The statistical comparisons were performed as described in materials and methods, and the abbreviations used are explained in Table 3. **p ≤ 0.01.
  2. wt: wild-type C57BL/6 mice, Tg: hemizygous transgenic mice containing human CYP2C18&19.