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Table 6 Comparisons of bone marrow parameters between genotypes of both sexes

From: Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model

Bone marrow parameter

♂

♀

 

Wt

Tg

Wt

Tg

TNC (*106/femur)

8.78 ± 0.995

9.27 ± 0.726

14.4 ± 2.71

11.7 ± 1.35

% Erythroid

37.8 ± 2.89

38.2 ± 3.51

33.6 ± 3.76

34.8 ± 5.88

% Lymphoid

12.0 ± 1.55

11.0 ± 1.40

8.41 ± 1.70

10.2 ± 1.48

% Myeloid

50.1 ± 3.38

50.6 ± 3.91

57.7 ± 4.81

54.6 ± 5.55

Ratio M: E

1.34 ± 0.188

1.35 ± 0.259

1.75 ± 0.342

1.64 ± 0.500

% LDS+

85.2 ± 2.19

85.7 ± 3.01

90.1 ± 2.60

89.4 ± 1.54

  1. The table shows the average bone marrow values for each group +/- standard deviations. The statistical comparisons were performed as described in materials and methods.
  2. wt: wild-type C57BL/6 mice, Tg: hemizygous transgenic mice containing human CYP2C18&19. TNC: Total Nucleated Count, % Erythroid/Lymphoid/Myeloid: Proportion (of total)
  3. Erythroid/Lymphoid/Myeloid cells, Ration M: E: Myeloid: Erythroid ratio, %LDS+: percentage of (total) cells staining positive for the nucleic acid stain LDC-751 (laser dye styryl-751).
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Acta Veterinaria Scandinavica

ISSN: 1751-0147