Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse

Table 1 Circulatory data (n = 7)

		Unsedated	Detomidine	Detomidine-butorphanol	GLM – ANOVA
HR	Beats/min	38 ± 8	23 ± 5*	29 ± 5*	p < 0.001
Qt	ml/min × kg	72 ± 14	32 ± 10*	44 ± 6*	p < 0.001
SV	ml/kg × beat	2.0 ± 0.7	1.4 ± 0.6	1.5 ± 0.3	NS
SAP mean	mmHg	116 ± 15	148 ± 14*	137 ± 14*	p < 0.001
PAP mean	mmHg	26 ± 2	34 ± 3*	31 ± 4*	p < 0.001
SVR	mmHg/ml/min × kg	1.69 ± 0.49	5.01 ± 1.45*	3.16 ± 0.62 *†	p < 0.001
PVR	mmHg/ml/min × kg	0.15 ± 0.06	0.31 ± 0.16*	0.15 ± 0.06†	p = 0.017
O ₂ del	ml/min × kg	11.4 ± 2.6	5.1 ± 1.8*	6.5 ± 0.8*	p < 0.001
C(a-v)O ₂	ml/100 ml	6.1 ± 0.8	8.5 ± 1.8*	7.3 ± 1.1	p = 0.002
Hb	g/l	1.15 ± 1.0	1.18 ± 1.3	1.11 ± 1.2	NS (p = 0.062)

Data presented as mean ± SD for heart rate (HR), cardiac output thermodilution (Qt), stroke volume (SV), mean systemic arterial pressure (SAP mean), mean pulmonary arterial pressure (PAP mean), systemic vascular resistance (SVR), pulmonary vascular resistance (PVR), oxygen delivery (O₂ del), arterial-mixed venous oxygen content difference (C(a-v)O₂) and haemoglobin concentration (Hb). Results for General Linear Model-ANOVA (GLM-ANOVA), p value for differences between the treatments, NS = non-significant. Differences between treatments are presented with the abbreviations: * = significantly different from unsedated, † = significantly different from detomidine sedation.

ISSN: 1751-0147