Figure 1
From: Evaluation of adverse effects in tamoxifen exposed healthy female dogs
Animal: C3, Pyometra. (A) Intact female dog with purulent vaginal discharge after oral administration of tamoxifen, 0.8 mg/kg/day, for 100 days. (B) Ultrasonography revealing uterine body (1.5 cm) and uterine horns slightly dilated, thickened uterine wall with irregular mucosa and retention of secretion within the organ. (C) Uterine histopathology after ovariohysterectomy revealing cystic endometrial hyperplasia type III associated with hemorrhage. HE, Obj. 4×. (D) Detail showing presence of polymorphonuclear cells in glandular lumen. HE, Obj. 60×.