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Table 1 Summary of genital tract symptoms and eye lesions.

From: Evaluation of adverse effects in tamoxifen exposed healthy female dogs

  

Days of tamoxyfen treatment

Group

Symptom

0

10

20

30

40

50

60

70

80

90

100

110

120

A

Oedema

0

5

5

5

5

5

5

5

5

5

5

3*

3*

 

Discharge

0

3

2

1

2

1

5

5

3

5

5

3*

3*

 

Retinitis

1

-

-

-

-

-

1

-

-

-

-

-

3

B

Oedema

0

5

5

5

5

5

5

5

5

5

5

5

5

 

Discharge

0

3

1

1

1

1

5

5

2

5

5

5

5

 

Retinitis

1

-

-

-

-

-

2

-

-

-

-

-

2

C

Oedema

0

5

5

5

5

5

5

5

5

3*

3*

1#

1#

 

Discharge

0

2

1

5

2

3

5

1

1

3*

3*

1#

1#

 

Retinitis

1

-

-

-

-

-

1

-

-

-

-

-

1

D

Oedema

0

5

5

5

5

5

5

5

5

5

5

5

5

 

Discharge

0

0

2

1

1

3

1

3

2

1

3

2

2

 

Retinitis

0

-

-

-

-

-

0

-

-

-

-

-

2

  1. * group size = 3, # group size = 1, - eyes not examined
  2. Number of dogs having vulva oedema, purulent vaginal discharge and retinitis following oral exposure to tamoxifen at daily doses of either 0.5 mg/kg body weight (groups A and B) or 0.8 mg/kg body weight (groups C and D). Dogs in groups B and D were spayed before the study. Each group consisted initially of 5 dogs, but animals developing pyometra or had eye lesions before tamoxifen exposure were removed from the study thus reducing the group size.
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Acta Veterinaria Scandinavica

ISSN: 1751-0147