Comparative study on the in vitro and in vivo properties of two bovine herpesvirus-5 reference strains

Table 2 Data obtained from calves (n = 8) experimentally inoculated with A663 and N569 strains of bovine herpesvirus (BoHV) 5.

Group	Animal no.	Viral excretion* (peak titre)	Severity of histopathological changes (mean)**	DNA in TG	SN Abs titre(log)***	Nasal IgA
BoHV-5 N569	636	2-12 (6)	+++	+	1.5	+
	628	7-15 (5)	++	+	1.05	-
	199	Intermittent (4.3)	-	-	1.5	+
	191	-	-	-	-	-
BoHV-5 A663	192	2-12 (6.5)	+++	+	0.9****	-
	619	2-6 (5.5)	+++	+	0.9	+
	185	Intermittent (2.3)	+	+	0.9	+
	254	2-12 (6.3)	+	+	0.9	+

*Viral excretion is expressed as log TCID₅₀/ml. **Score based on the presence of the following CNS histopathological alterations: vascular alteration, inflammation, focal gliosis, infiltration by macrophages and malacia. References: +++: severe; ++: moderate; +: slight; -:negative. ***Serum neutralizing (SN) antibodies (Abs) at day 34 post infection (pi). ****Animal 192 was euthanized 15 days pi, the titre of SN Abs corresponds to this date.

ISSN: 1751-0147