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Table 2 MICs of β-lactam antibiotics for 38 cefazolin-resistant isolates of E. coli from diseased animals isolated between 2002 and 2006

From: Phylogenetic groups and cephalosporin resistance genes of Escherichia coli from diseased food-producing animals in Japan

     

MICs (μg/ml) of:

Animal species

β-lactamase

n

Year isolated

Phylogenetic group

Cefazolin

Cefpodoxime

Cefotaxime

Ceftazidime

Aztreonam

Imipenem

Meropenem

     

(32)*

(8)

(64)

(32)

(32)

(16)

(16)

Cattle

CTX-M-2

1

2003 (1)

A (1)

256

>32

>32

4

16

≤1

≤4

 

CTX-M-2/TEM-1

1

2003 (1)

B1 (1)

256

>32

>32

8

>16

≤1

≤4

 

CMY-2

1

2003 (1)

A (1)

256

8

≤1

≤1

≤4

≤1

≤4

 

CMY-2/TEM-1

1

2002 (1)

D (1)

256

>32

8

16

≤4

≤1

≤4

 

TEM-1

1

2003 (1)

A (1)

32

8

≤1

2

≤4

≤1

≤4

 

ND

1

2002 (1)

B1 (1)

128

16

≤1

8

≤4

≤1

≤4

Poultry

CTX-M-2

1

2006

A (1)

>512

>32

>32

2

≤4

≤1

≤4

 

CTX-M-15/TEM-1

1

2006

A (1)

>512

>32

>32

32

8

≤1

≤4

 

CTX-M-25

4

2005(3), 2006 (1)

A (2), D (2)

>512

>32

16->32

2-4

≤4-8

≤1

≤4

 

SHV-2

3

2004 (3)

A (3)

256-512

32->32

8-32

4-16

≤4-8

≤1

≤4

 

CMY-2

10

2004(1), 2006 (10)

A (5), B1 (1), D (5)

512->512

>32

4-32

8-32

≤4-8

≤1

≤4

 

TEM-1

7

2004 (2), 2005 (5)

A (7)

64->512

16-32

≤1-2

4-8

≤4

≤1

≤4

 

ND

2

2002 (1), 2005 (1)

A (2)

128-256

16-32

≤1-2

4

≤4

≤1

≤4

Swine

CMY-2/TEM-1

1

2004 (1)

A (1)

>512

>32

16

32

16

≤1

≤4

 

ND

2

2002 (1), 2003 (1)

A (1), D (1)

128-256

4-8

≤1

≤1

≤4

≤1

≤4

  1. * Resistance breakpoint (μg/ml) defined by CLSI guideline.