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Table 2 Summary of toxicokinetic variables in various compartments (blood and hair).

From: Toxicokinetics of mercury in blood compartments and hair of fish-fed sled dogs

 

Compartment

Hg at week 12

(ppb)

Time to Plateaua (weeks)

keb

(weeks-1)

t1/2

(weeks)

Ratio Hg

Hair:Bloodc

dog C

WB:

11.36

8

-0.14

-5.0

62

 

PCp:

18.98

8

-0.14

-4.9

 
 

PCs:

16.80

6

-0.14

-5.1

 
 

Hair:

704.9

    

dog K

WB:

6.58

2

-0.16

-4.3

69

 

PCp:

10.64

4

-0.21

-3.3

 
 

PCs:

9.60

3

-0.21

-3.4

 
 

Hair:

456.6

    

dog M

WB:

9.27

6

-0.09

-7.5

52

 

PCp:

12.99

8

-0.09

-7.7

 
 

PCs:

13.24

8

-0.09

-7.6

 
 

Hair:

488.1

    

dog T

WB:

9.57

4

-0.10

-7.3

54

 

PCp:

15.28

6

-0.11

-6.6

 
 

WB:

9.57

4

-0.10

-7.3

54

 

PCp:

15.28

6

-0.11

-6.6

 
 

PCs:

13.71

4

-0.11

-6.6

 
 

Hair:

526.0

    

Average d

WB:

9.2 ± 1.97

3

-0.10

-7.0

59 ± 7.6

all fish-

PCp:

14.2 ± 3.18

6

-0.11

-6.6

 

fed dogs

PCs:

13.3 ± 2.95

6

-0.10

-6.9

 
 

Hair:

544 ± 111.0

    
  1. Total mercury (Hg) concentration was determined at the end of fish exposure (week 12) for the fish-fed dogs and the rates to plateau and elimination for the different blood compartments (whole blood (WB), packed cells from plasma (PCp) and packed cells from serum (PCs)) were calculated.
  2. aTime to plateau was determined as the earliest time point found not to vary significantly from Hg concentration at week 12 (α = 0.05).
  3. bke is the first order elimination constant
  4. cRatio = Hg Hair (ppm)/Hg Whole Blood (ppm)
  5. dAnalysis was done on the average of the combined parameter results
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Acta Veterinaria Scandinavica

ISSN: 1751-0147