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Table 1 Mean values (± SD) of pharmacokinetic parameters for ketoprofen after PO or IM administration of a single dose in a cross-over design to 11 crossbred pigs

From: Enantiospecific ketoprofen concentrations in plasma after oral and intramuscular administration in growing pigs

 

Route of administration

Parameter

PO 4 mg/kg

IM 3 mg/kg

Cmax (mg/L)

S-Ketoprofen

7.42 ± 2.35*

7.32 ± 0.75*

 

R-Ketoprofen

2.55 ± 0.99

3.23 ± 0.70

Tmax (h)

S-Ketoprofen

1.91 ± 1.65*

1.27 ± 0.45*

 

R-Ketoprofen

0.59 ± 0.23

0.65 ± 0.30

AUC0-∞ ([mg/L] h)

S-Ketoprofen

47.04 ± 13.41*

44.09 ± 12.87*

 

R-Ketoprofen

3.83 ± 1.23

5.16 ± 2.48

AUC0-24 ([mg/L] h)

S-Ketoprofen

46.26 ± 12.77*

43.46 ± 12.88*

 

R-Ketoprofen

3.54 ± 1.17

4.53 ± 2.19

AUC24-∞ (%)

S-Ketoprofen

1.56 ± 1.63

1.55 ± 1.77

 

R-Ketoprofen

7.13 ± 8.83

12.06 ± 10.12

T1/2 (h)

S-Ketoprofen

3.40 ± 0.91*

2.89 ± 0.85*

 

R-Ketoprofen

1.1 ± 0.90

0.75 ± 0.48

MRT (h)

S-Ketoprofen

5.55 ± 1.45*

4.91 ± 1.21*

 

R-Ketoprofen

1.73 ± 0.92

1.49 ± 0.67

AUCS/AUCR ratio

12.8 ± 3.17**

9.2 ± 2.39

  1. * Denotes a significant difference (P < 0.05) between S-ketoprofen and R-ketoprofen when comparing within treatments.
  2. ** Denotes a significant difference (P < 0.05) between administration routes (PO versus IM).