| Route of administration | ||
---|---|---|---|
Parameter | PO 4 mg/kg | IM 3 mg/kg | |
Cmax (mg/L) | S-Ketoprofen | 7.42 ± 2.35* | 7.32 ± 0.75* |
 | R-Ketoprofen | 2.55 ± 0.99 | 3.23 ± 0.70 |
Tmax (h) | S-Ketoprofen | 1.91 ± 1.65* | 1.27 ± 0.45* |
 | R-Ketoprofen | 0.59 ± 0.23 | 0.65 ± 0.30 |
AUC0-∞ ([mg/L] h) | S-Ketoprofen | 47.04 ± 13.41* | 44.09 ± 12.87* |
 | R-Ketoprofen | 3.83 ± 1.23 | 5.16 ± 2.48 |
AUC0-24 ([mg/L] h) | S-Ketoprofen | 46.26 ± 12.77* | 43.46 ± 12.88* |
 | R-Ketoprofen | 3.54 ± 1.17 | 4.53 ± 2.19 |
AUC24-∞ (%) | S-Ketoprofen | 1.56 ± 1.63 | 1.55 ± 1.77 |
 | R-Ketoprofen | 7.13 ± 8.83 | 12.06 ± 10.12 |
T1/2 (h) | S-Ketoprofen | 3.40 ± 0.91* | 2.89 ± 0.85* |
 | R-Ketoprofen | 1.1 ± 0.90 | 0.75 ± 0.48 |
MRT (h) | S-Ketoprofen | 5.55 ± 1.45* | 4.91 ± 1.21* |
 | R-Ketoprofen | 1.73 ± 0.92 | 1.49 ± 0.67 |
AUCS/AUCR ratio | 12.8 ± 3.17** | 9.2 ± 2.39 |