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Kinetics of Intravenously Administered Lactose in Cows

Laktosekinetikk hos ku

Abstract

Four adult Norwegian Red cows were employed in an experiment designed to study the kinetics of lactose. The cows were given 50 g or 60 g of lactose by rapid intravenous injection of a 10 % lactose solution. Blood samples were taken at different intervals after injection, and lactose concentrations in the samples determined by an enzymatic/spectrophotometric method.

The mean half-time for lactose elimination was 85.7 min, and for distribution 8.4 min. The mean apparent volume of distribution was calculated to be 0.189 1/kg, and total body clearance 1.55 ml min−1 kg−1.

There was evidence to suggest that lactose mainly is eliminated renally from its distribution volume by glomerular filtration in the cow.

Sammendrag

Fire voksne NRF-kuer (Norsk rødt fe) ble benyttet i dette eksperimentet for å studere laktosekinetikk.

Kuene fikk 50 g eller 60 g laktose som en hurtig intravenøs injeksjon av en 10 % laktoseoppløsning. Blodprøver ble tatt på forskjeilig tidspunkt etter injeksjonen og laktoisekonsentrasjonen i prøvene ble bestemt ved en enzymatisk/spektrofotometrisk metode.

Den gjennomsnittlige halveringstiden for laktose eliminasjon var 85,7 minutter, og halveringstiden for distribusjon var 8,4 minutter. Det gjennomsnittlige tilsynelatende distribusjonsvolum ble beregnet til 0,189 1/kg og total clearance til 1,55 ml min−1 kg−1.

Det var holdepunkter for å anta at laktose elimineres renalt fra distribusjonsvolumet ved glomerulær filtrasjon hos ku.

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Moe, L., Havre, G.N. Kinetics of Intravenously Administered Lactose in Cows. Acta Vet Scand 26, 493–500 (1985). https://doi.org/10.1186/BF03546521

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