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Spontaneous Aortic Lesions in Fallow Deer (Dama Dama L)

Spontana aortaskador hos douhjort (Dama dama L)


In 19 out of 22 aortas from fallow deer, 15 months to 5½ years, aortic lesions were found. Three types of lesions were observed, fatty streaks were seen in 2, fibrous plaques in 15 and fibrous plaques with complicated lesions (calcification and acid mucopolysaccharides) in 2 of the aortas. Elastic tissue degeneration of the inner two thirds of the tunica media was frequently found in the aorta of the animals > 3½–5½ years of age. There was no statistical evidence for a correlation between age and frequency (P ~ 0.10) but a trend towards age dependence was seen. The percentage of involved surface was found to significantly increase (0.05 > P > 0.01) with age. Lesions were found to start in the abdominal aorta in young animals and to extend cranially to the thoracic aorta with age. The percentage of involved surface in different affected regions, comprising all age groups were, in the posterior abdominal portion, 10.5 %, in the anterior abdominal portion, 4.3 % and in the posterior thoracic portion, 1.04 %. The influence of hemodynamic flow upon the localization of the aortic lesions, the endothelial cell population density and the endothelial nuclear patterns were discussed.


Hos 19 av 22 dovhjortar, 15 månader—5½ år gamla, påvisades skador i aorta. Tre olika typer av skador förelåg; stråk av fett i 2, fibrösa knutor i 15 och fibrösa knutor med komplicerande skador (förkalkning och sura mucopolysaccharider) i 2 aortor. Degeneration av elastisk vävnad, i de inre två tredjedelarna av tunica media, fanns frekvent i aorta från djur äldre än 3½ år. Det förelåg in get statistiskt säkerställt förhållande melian ålder och frekvens men däremot en tendens till åldersbetingelse. Procenten förändrad yta ökade signifikant (0,05 > P > 0,01) med stigande ålder. Förändringarna befanus börja i abdominala aorta hos unga djur och med stigande ålder utbredde de sig till den thorakala aortan.

Frekvensen inbegrip en yta i olika skadade delar, omfattande alla åldersgrupper var; bakre abdominala aortan 10,5 %, främre abdominala aortan 4,3 % och bakre thorakala delen av aorta 1,4 %. Flöde av hemodynamiskt påverkan vad avser lokalisationen av skadorna diskuteras liksom även tätheten av den endotheliala cellproduktionen och kärnornas positioner hos endothelcellarna.


  • Ahlen, I.: Winter habitant of moose and deer in relation to land use in Scandinavia. Swedish Wildlife 1975, 9, 45–192.

  • Armstrong, N., R. E. Chaplin, D. I. Chapman & B. Smith: Observation on the reproduction of female wild and park fallow deer (Dama Dama) in Southern England. J. Zool. Lond. 1969, 158, 27–37.

    Article  Google Scholar 

  • Bell, F. P., A. J. Day, M. Gent & C. J, Schwartz: Different patterns of cholesterol accumulation and 3H-cholesterol on influx in areas of the cholesterol-fed pig aorta identified by Evan blue dye. Exp. molec. Path. 1977, 22, 366–375.

    Article  Google Scholar 

  • Borensztajn, J., S. Otway & D. S. Robinson: Effect of fasting of the clearing factor lipase (Lipo-protein lipase) activity of fresh and defatted preparation of rat heart muscle. J. Lipid Res. 1970, 11, 102–110.

    CAS  PubMed  Google Scholar 

  • Borg, K.: On mortality and reproduction of roe deer in Sweden during the period 1949–1969. Swedish Wildlife 1970, 7, 121–149.

    Google Scholar 

  • Crawford, T. & C. L Levene: The incorporation of fibrin in the aortic intima. J. Path. Bact. 1952, 64, 523–528.

    Article  CAS  Google Scholar 

  • Day, A. J., F. P. Bell & C. J. Schwartz: Lipid metabolism in focal areas of normal fed and cholesterol-fed pig aortas, Exp. molec. Path. 1974, 21, 179–193.

    Article  CAS  Google Scholar 

  • Dow, D. R.: The incidence of arteriosclerosis in the artery of the body. Brit. med. J. 1952, 2, 168.

  • Duguid, J. B.: Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. J. Path, Bact. 1946, 58, 207.

  • Flaherty, J. T., J. E. Pierce, V. J. Ferrans, D. J. Patal, W. K. Tucker & D. L. Fry: Endothelial nuclear patterns in the cranial arterial tree with particular reference to hemodynamic events. Cir. Res. 1972, 30, 23–33.

    Article  CAS  Google Scholar 

  • Friedman, M. & S. O. Byers: Experimental thrombo-atherosclerosis. J. clin. Invest. 1961, 40, 1139–1152.

    Article  CAS  Google Scholar 

  • Friedman, M. & S. O. Byers: Excess lipid leakage, a property of very young vascular endothelium. Brit. J. exp. Path. 1962, 43, 363–372.

    CAS  PubMed  Google Scholar 

  • Friedman, M. & S. O. Byers: Endothelial permeability in atherosclerosis. Arch. Path. 1963, 76, 99–105.

    CAS  PubMed  Google Scholar 

  • Fry, D. L.: Acute vascular endothelial changes associated with increased blood velocity gradients. Cir. Res. 1968, 22, 165–197.

    Article  CAS  Google Scholar 

  • Getty, R.: The gross and microscopic occurrence and distribution of spontaneous atherosclerosis in the arteries of swine. In: Comparative atherosclerosis. Edit. by Robert, J. C, R. Straus and M. R. Cooper. Hoeber medical division, Harper and Row Publ. New York 1965, p. 11–20.

  • Gupta, P. & C. Rehbinder: Spontaneous aortic lesions in reindeer (Rangifer tarandus L). Acta vet. scand. 1981, 22, 60–66.

    CAS  PubMed  Google Scholar 

  • Hollenberg, C. H.: The effect of fasting on activity and release of lipase from rat adipose tissue. Amer. J. Physiol. 1959, 197, 667–670.

    Article  CAS  Google Scholar 

  • Hollenberg, C. H.: The effect of fasting on the lipoprotein lipase activity on rat heart and diaphragm. J. clin. Invest. 1960, 39, 1282–1287.

    Article  CAS  Google Scholar 

  • Holman, R. L., H. C. McGill, J. F. Strong & J. C. Geer: The natural history of atherosclerosis (The early aortic lesions as seen in New Orleans in the middle of the 20th century). Amer. J. Path. 1958, 34, 209–235.

    CAS  PubMed  Google Scholar 

  • Jaeger, M.: The flow through the arterial wall. In : Pulsatic blood flow. Edit, by Attingec, E. O., McGraw Hill, New York 1964, p. 307–372.

  • Junqueira, I. C., J. Carneiro & A. Contopoulos: Circulatory system. In: Rasic History. 2nd ed. Inter, standard book, Canada 1977, p. 218–224.

  • Mallou, J.: Cold effects in rat, plasma and adipose tissue free fatty acid and adipose lipase. Amer. J. Physiol. 1963, 204, 157–164.

    Article  Google Scholar 

  • Moore, S. & O. Thnatowycz: Vessel injury and atherosclerosis. Adv. exp. Med. Biol. 1978, 102, 145–164.

    Article  CAS  Google Scholar 

  • Paterson, J. C., J. Mills & T. Moffatt: Vascularization of early atherosclerotic plaques. Arch. Path. 1957, 64, 129–136.

    CAS  Google Scholar 

  • Poole, J. C., A. G. Sanders & H. W. Florey: The regeneration of aortic endothelium. J. Path. Bact. 1958, 75, 135–143.

    Google Scholar 

  • Poungshompoo, S. & C. Rehbinder: Spontaneous aortic lesions in roe deer (Capreolus capreolus L). Acta vet. scand. 1983, 24, 153–169.

    CAS  PubMed  Google Scholar 

  • Poungshompoo, S. & C. Rehbinder: Spontaneous aortic lesions in moose (Alces alces L). Acta vet. scand. 1985, 26, 533–548.

    CAS  PubMed  Google Scholar 

  • Robert, J. C. Jr., C. Moses & R. H. Wilkins: Autopsy studies in atherosclerosis. I. Distribution and severity of atherosclerosis in patients dying without morphological evidence of atherosclerotic catastrophe. Circulation 1959, 20, 511.

  • Robinson, D. S.: The effect of change in nutritional state on the lipolytic activity of rat adipose tissue. J. Lipid Res. 1960, 1, 332–338.

    CAS  PubMed  Google Scholar 

  • Ross, R. & L. Harker: Hyperlipidemia and atherosclerosis, chronic hyperlipidemia initiates and maintains lesions by endothelial cell degeneration and lipid accumulation. Science 1976, 93, 1094–1100.

    Article  Google Scholar 

  • Sako, Y.: Effects on turbulent blood flow and hypertension on experimental atherosclerosis. J. Amer. med. Ass. 1962, 179, 36–40.

    Article  CAS  Google Scholar 

  • Sandhoefer. F., S. Sailer & H. Brannsteiner: Untersuchungen über endogene lipoproteinlipaseaktivität. (Investigations on endogenous lipoproteinlipase activity). Klin. Wschr. 1962, 40, 885.

  • Skold, E. H. & R. Getty: Spontaneous atherosclerosis in swine. J. Amer. vet. med. Ass. 1961, 139, 665.

  • Still, W. L. S.: An electron microscopic study of the organization of experimental thromboemboll in the rabbit. Lab. Invest. 1966, 15, 1429–1507.

    Google Scholar 

  • Texton, M., A. M. Imperato & M. Helpern: The role of vascular dynamic in the development of atherosclerosis. J. Amer. med. Ass. 1965, 194, 168–170.

    Article  Google Scholar 

  • Wissler, R. W.: Overviews problems of atherosclerosis. In: Cerebro vascular disease. Edit, by P. Scheinberge, Revan Press, New York 1976, p. 59–75.

  • WHO Study Group on Atherosclerosis: Classification of atherosclerotic lesions. Tech. Rep. Ser., Wld. Hlth. Org. No. 143, WHO, Geneva 1958, p. 1–22.

  • Wolf, M. L.: Age determination in moose from cementai layers of molar teeths. J. Wildl. Managem. 1969, 33, 428–431.

    Article  Google Scholar 

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Poungshompoo, S., Rehbinder, C. Spontaneous Aortic Lesions in Fallow Deer (Dama Dama L). Acta Vet Scand 26, 549–562 (1985).

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