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Some Aspects of Murine Experimental Listeriosis

Vissa aspekter på experimentell listerios hos möss

Acta Veterinaria Scandinavica volume 26, pages 563–580 (1985)Cite this article

Abstract

A set of experiments was carried out in order to approach the complex nature of L. monocytogenes infections from different aspects. Experiment 1 showed that Listeria are able to gain admission to body by numerous ways and both subcutaneous and oral entry can lead to fatal septicemia. It also gave slight support to the theory of direct neural transmission of Listeria to the brain and indicated the possibility that intestinal absorption after oral exposition at least partly occurs via lymphatic vessels. No inflammatory reaction could be caused to mice by ocular flushing with Listeria suspension.

The second trial proved that there are vast differences in the animal pathogenecity of Listeria strains — even among those of the same serotype. In experiment 3A the abolishing effect of dextran sulfate on the early resistance of mice to Listeria was confirmed and it turned out that cortisone at a therapeutic dose level did not bring about that phenomenon. Levamisole granted no conspicuous enhancement of resistance in this acute challenge; however, the results of the immunity test (3B) suggested that levamisole may be beneficial during the induction phase. On the other hand, starvation appeared to impair long-term immunity. Likewise, in experiment 4 starved mice were quite susceptible to acute challenge with Listeria. Raised ambient temperature, on the contrary, prominently increased the survival rate of the animals.

Owing to the fairly small number of animals these results should be regarded as preliminary starting points to further studies.

Sammanfattning

En serie på fyra experiment om listerios hos mösis utfördes. Det blev visat, att Listeria (L.) -organismer kan intränga i djuret via olika vägar och att både subkutant och oralt inträde kan leda till letal septikemi. Det fanns också tecken på neural spridning och tarmabsorption via lymfkärl av L. Ingen inflammatorisk reaktion kunde vållas med okular spolning med L.-suspension. Patogeniteten av L,-stammar (som tillhörde samma serotyp) varierade mycket. DS-500 fördärvade mössens tidiga resistens emot L., men kortison på terapeutisk dosnivå åstadkom det inte. Någon nyttig effekt av levamisol observerades inte vid akut blottställning, men resultaten tydde på att den skulle kunna vara gynnsam vid produktion av immunitet. Fastan tycktes försämra mössens immunitet och motståndsförmåga; förhöjd temperatur däremot ökade antalet överlevande djur.

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  1. National Veterinary Institute, P. O. B 92, 70701, Kuopio, Finland

    Raimo Pohjanvirta & Tarja Huttunen

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  1. Raimo Pohjanvirta
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  2. Tarja Huttunen
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Pohjanvirta, R., Huttunen, T. Some Aspects of Murine Experimental Listeriosis. Acta Vet Scand 26, 563–580 (1985). https://doi.org/10.1186/BF03546527

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Acta Veterinaria Scandinavica

ISSN: 1751-0147