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Effects of Oscillatoria Agardhii-Toxins on Blood Pressure and Isolated organ Preparations
Virkninger av Oscillatoria agardhii-toksin på blodtrykk og isolerte organpreparater
Acta Veterinaria Scandinavica volume 26, pages 374–384 (1985)
Abstract
Toxic extracts of the blue-green alga Oscillatoria agardhii were tested for their effect on various isolated laboratory animal preparations. The Oscillatoria-toxins did not show hemagglutinative or hemolytical properties. An immediate rise in blood pressure was seen after intravenous injection in rats. As regards isolated organs, effects were most marked on the liver. Addition of toxic extract to isolated liver perfusion fluid led to physiological, biochemical and pathological changes indicating severe damage to the organ. Negative chronotropic and inotropic effects were found on the isolated heart. The toxins did not influence isolated smooth muscle or nerve striated muscle preparations.
Sammendrag
Toksiske ekstrakter av blågrønnalgen Oscillatoria agardhii ble undersøkt m. h. p. effekt på ulike isolerte laboratoriedyrpreparater. Oscillatoriatoksinet viste ikke hemagglutinerende eller hemolyserende egenskaper. En umiddelbar blodtrykksstigning ble sett etter intravenøs injeksjon på rotter. På isolerte organer fant en hovedsaklig effekt på leveren. Tilsetning av toksisk ekstrakt til leverperfusjonsløsningen ga fysiologiske, biokjemiske og patologiske forandringer som viste alvorlig skade på organet. På isolert hjerte fant en en negativ kronotrop og inotrop effekt. Toksinene virket ikke inn på isolert glatt muskel eller nerve-tverrstripet muskelpreparater.
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Berg, K., Søli, E. Effects of Oscillatoria Agardhii-Toxins on Blood Pressure and Isolated organ Preparations. Acta Vet Scand 26, 374–384 (1985). https://doi.org/10.1186/BF03546537
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DOI: https://doi.org/10.1186/BF03546537