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Suppression of Babesia Microti Infection in Mice Concurrently Infected with Schistosoma Mansoni

Suppression af Babesia microti infektion hos mus med samtidig infektion med Schistosoma mansoni

Acta Veterinaria Scandinavica volume 26, pages 191–204 (1985)Cite this article

Abstract

Blood cell panasitaemias of Babesai microti and associated haematological changes were studied in mice concurrently infected with Schistosoma mansoni and in controls with no schistosome infections. In comparison to the controls B. microti parasit-aemias were suppressed markedly in mice harbouring 6 and 8 weeks old patent S. mansoni infections at the time of infection with B. microti. The suppression was accompanied by an alleviation/annulment of the B. microti induced reductions in haemoglobin and haematocrit levels and in its erythropoetic stimulation. The suppressive effect of patent S. mansoni infections on B. microti is suggested to be at least partly attributable to non-specific immunological factors although the altered erythrocyte kinetic state induced by the schistosoma infection in combination with the preference of B. microti for mature (old) erythrocytes might also play a role in the suppression. In mice harbouring 2 weeks old prepatent S. mansoni infections B. microti was not suppressed.

Sammendrag

Babesia microti parasitæmien og haematologiske forandringer blev undersøgt hos henholdsvis mus med samtidig infektion med Schistosoma mansoni og hos kontrolmus uden schistosominfektion. B. microti parasitæmien blev suppreret i betydelig grad hos mus der var blevet inficerede med S. mansoni 6 og 8 uger tidligere. Denne suppression blev ledsaget af en reduktion/ophævelse af den af B. microti forårsagede reduktion i hæmoglobin og hæmatokrit niveauerne og af B. microti’s bidrag til erythropoesens størrelse. Den suppressive effekt af patente S. mansoni infektioner på B. microti formodes i det mindste delvis at være forårsaget af non-specifikke immunologiske faktorer, men den af schistosominfektionen forårsagede ændring i erythrocyt-omsætningen sammenholdt med B. microti’s præference for mature (gamle) erythrocytter kan muligvis også være en medvirkende årsag til suppressionen. I mus, der var blevet inficerede med S. mansoni 2 uger før infektionen med B. microti, forekom der ingen suppression af protozoinfektionen.

References

  • Bailenger, J. & M. Guy: Interactions de deux parasitoses associées chez le rat: Plasmodium berghei et Strongyloides ratti. (Interactions between two parasite infections in the rat: Plasmodium berghei and Strongyloides ratti). Ann. parasitol. 1982, 57, 513–516.

    CAS  Google Scholar 

  • Bell, E. A.: A new method for counting Schistosoma mansoni eggs in faeces. Bull. WHO 1963, 29, 525–530.

    CAS  PubMed  Google Scholar 

  • Buck, A. A., R. I. Anderson, A. A. MacRae & A. Fain: Epidemiology of poly-parasitism: I. Occurrence, frequency and distribution of multiple infections in rural communities in Chad, Peru, Afghanistan and Zaire. Tropenmed. Parasitol. 1978a, 29, 61–70.

    CAS  PubMed  Google Scholar 

  • Buck, A. A., R. I. Anderson, A. A. MacRae & A. Fain: Epidemiology of poly-parasitism: II. Type of combinations, relative frequency and association of multiple infections. Tropenmed. Parasitol. 1978b, 29, 137–144.

    CAS  Google Scholar 

  • Cox, F. E. G.: Factors affecting infections of mammals with intraerythrocytic protozoa. Symp. Soc. exp. Biol. 1975, 29, 429–451.

    Google Scholar 

  • Fagbemi, B., N. Ø. Christensen & P. Nansen: Suppression of Babesia microti infection in mice concurrently infected with Fasciola hepatica. Vet. Parasitol. 1985, 17, 101–110.

    Article  CAS  Google Scholar 

  • Hussein, H. S.: Babesia hylomysci in mice: Preference for erythrocytes of a particular age-group and pathogenesis of the anaemia. Z. Parasitenkd. 1976, 50, 103–108.

    Article  CAS  Google Scholar 

  • King, M.: A Medical Laboratory for Developing Countries. Oxford University Press, London 1973.

  • Kloetzel, K., J. J. Faleiros, S. R. Mendes, C. T. Stanley & H. J. Arias: Concomitant infection of albino mice by Trypanosoma cruzi and Schistosoma mansoni. Parasitological parameters. Trans. Roy. Soc. trop. Med. Hyg. 1973, 67, 652–658.

    Article  CAS  Google Scholar 

  • Landsberg, J. W. & L. C. Eskridge: The erythrocyte in Babesia canis. J. Parasitol. 1940, 26, 377–385.

    Article  Google Scholar 

  • Lwin, M., C. Last, G. A. T. Targett & M. J. Doenhoff: Infection of mice concurrently with Schistosoma mansoni and rodent malarias: contrasting effects of patent S. mansoni infections on Plasmodium chabaudi, P. yoelii and P. berghei. Ann. trop. Med. Parasitol. 1982, 76, 265–273.

    CAS  PubMed  Google Scholar 

  • Mahmoud, A. A. F. & A. W. Woodruff: Mechanisms involved in the anaemia of schistosomiasis. Trans. Roy. Soc. trop. Med. Hyg. 1972, 66, 75–84.

    Article  CAS  Google Scholar 

  • McHardy, N.: Effects of stimulating erythropoesis in mice infected with Babesia rodhaini. Ann. trop. Med. Parasitol. 1973, 67, 301–306.

    Article  CAS  Google Scholar 

  • Ngwenya, B. Z.: Enhanced resistance to Plasmodium berghei in mice previously infected with Trichinella spiralis. Parasite Immunol. 1982, 4, 197–207.

    Article  CAS  Google Scholar 

  • Phillips, R. S.: The role of the spleen in relation to natural and acquired immunity to infections of Babesia rodhaini in the rat. Parasitology 1969, 59, 637–648.

    Article  CAS  Google Scholar 

  • Roberts, J. A., J. D. Kerr & P. Tracey-Patte: Function of the spleen in controlling infections of Babesia rodhaini in mice. Int. J. Parasitol. 1972, 2, 217–226.

    Article  CAS  Google Scholar 

  • Schroeder, W. F., H. W. Cox & M. Ristic: Anaemia, parasitaemia, erythrophagocytosis and haemaglutinins in Babesia rodhaini infection. Ann. trop. Med. Parasitol. 1966, 60, 31–38.

    Article  CAS  Google Scholar 

  • Simons, H.: Sur les rapport des plasmodies paludiques et des piroplasmose avec les reticulocytes. (The relationship between plasmodia and piroplasms and the reticulocytes). Ann. Parasitol. 1939, 17, 72–85.

    Google Scholar 

  • Smithers, S. R. & R. J. Terry: The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 1965, 55, 695–700.

    Article  CAS  Google Scholar 

  • Todorovic, R., D. Ferris & M. Ristic: Roles of the spleen in acute plas-modial and babesial infections in rats. Exp. Parasitol. 1967, 21, 354–372.

    Article  CAS  Google Scholar 

  • World Health Organization: Immunology of schistosomiasis. Bull WHO 1974, 51, 553–595.

    Google Scholar 

  • Willett, K. C.: An observation on the unexpected frequency of some multiple infections. Bull. WHO 1972, 47, 747–749.

    CAS  PubMed  Google Scholar 

  • Yusuf, J. N., G. Pierkarski & B. Pelster: Concurrent infections of Trichinella spiralis and Toxoplasma gondii in mice. Z. Parasitenkd. 1980, 62, 231–240.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Danish Bilharziasis Laboratory and Institute of Veterinary Microbiology and Hygiene, Royal Veterinary and Agricultural University, Jægersborg Allé 1 D, DK-2920, Charlottenlund, Denmark

    Benjamin Fagbemi, Niels Ørnbjerg Christensen & Peter Nansen

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  1. Benjamin Fagbemi
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  2. Niels Ørnbjerg Christensen
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  3. Peter Nansen
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Fagbemi, B., Christensen, N.Ø. & Nansen, P. Suppression of Babesia Microti Infection in Mice Concurrently Infected with Schistosoma Mansoni. Acta Vet Scand 26, 191–204 (1985). https://doi.org/10.1186/BF03546551

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Acta Veterinaria Scandinavica

ISSN: 1751-0147